535-32-0

Basic information

• Product Name: D-ETHIONINE
• Synonyms: H-D-ETH-OH;D-2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID;D(-)-ETHIONINE;D-ETHIONINE;d-butyricaci;D-ETHIONINE 98%;(-)-S-Ethyl-D-homocysteine;(R)-2-Amino-4-(ethylthio)butyric acid
• CAS NO: 535-32-0
• Molecular Formula: C₆H₁₃NO₂S
• Molecular Weight: 163.24
• EINECS: 208-612-1
• Product Categories: Amino Acids 13C, 2H, 15N;Amino acids methyl、ethyl、t-butyl series;Amino Acids & Derivatives
• Mol File: 535-32-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 278 °C (dec.)(lit.)
• Boiling Point: 310.4 °C at 760 mmHg
• Flash Point: 141.5 °C
• Appearance: /solid
• Density: 1.085 (estimate)
• Vapor Pressure: 0.000133mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: -20°C Freezer
• Solubility: Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly)
• PKA: 2.23±0.10(Predicted)
• CAS DataBase Reference: D-ETHIONINE(CAS DataBase Reference)
• NIST Chemistry Reference: D-ETHIONINE(535-32-0)
• EPA Substance Registry System: D-ETHIONINE(535-32-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• RTECS: ES6825100
• Hazardous Substances Data: 535-32-0(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

Uses

An Amino Acid derivative.

Definition

ChEBI: An S-ethylhomocysteine that has R-configuration at the chiral centre.

InChI:InChI=1/C6H13NO2S/c1-2-10-4-3-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)/t5-/m1/s1

Synthetic route

S-benzyl-D-homocysteine (13073-47-7) → D-Ethionine (535-32-0)

Conditions	Yield
With ammonia; sodium dann Einwirkung von Aethylbromid;

N-acetyl-S-ethyl-D-homocysteine → D-Ethionine (535-32-0)

Conditions	Yield
With hydrogenchloride

D-Ethionine (535-32-0) → 4-ethylsulfanyl-2-oxo-butyric acid (36506-17-9)

Conditions	Yield
With D-amino acid:oxygen-oxidoreduktase

D-Ethionine (535-32-0) → D-Ethioninol (85803-42-5)

Conditions	Yield
With borane-THF; boron trifluoride diethyl etherate In tetrahydrofuran for 12h; Ambient temperature; Yield given;

D-Ethionine (535-32-0) + methyl chloroformate (79-22-1) → N-methoxycarbonyl-D-ethionine

Conditions	Yield
With sodium hydroxide at 0 - 20℃; pH=10.5;

D-Ethionine (535-32-0) → N-methoxycarbonyl-D-ethionine methyl ester (475640-44-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. NaOH / 0 - 20 °C / pH 10.5 2: aq. HCl / 12 h / Heating View Scheme

D-Ethionine (535-32-0) → N-methoxycarbonyl-D-ethionine methyl ester sulfoxide

Conditions	Yield
Multi-step reaction with 3 steps 1: aq. NaOH / 0 - 20 °C / pH 10.5 2: aq. HCl / 12 h / Heating 3: aq. H2O2 / methanol / -20 °C View Scheme

Upstream product

• 13073-47-7 S-benzyl-D-homocysteine