535-52-4

Basic information

• Product Name: 2-Fluoro-5-(trifluoromethyl)aniline
• Synonyms: 3-Amino-4-fluorobenzotrifluoride for synthesis;4-FLUORO-3-AMINOBENZOTRIFLUORIDE;3-AMINO-4-FLUOROBENZOTRIFLUORIDE;ALPHA,ALPHA,ALPHA,6-TETRAFLUORO-M-TOLUIDINE;2-FLUORO-5-(TRIFLUOROMETHYL)ANILINE;2-Fluoro-5-(Trifluoromethyl)Aniline/3-Amino-4-Fluorobenzotrifluoride;4-Fluoro-3-Aminotrifluoromethylbenzene;3-Amino-4-fluorobenzotrifluoride, 97% (2-Fluoro-5-(trifluoromethyl)aniline)
• CAS NO: 535-52-4
• Molecular Formula: C₇H₅F₄N
• Molecular Weight: 179.11
• Product Categories: Trifluoromethylbenzene serise;Anilines, Aromatic Amines and Nitro Compounds;Aniline;Miscellaneous
• Mol File: 535-52-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 155 °C(lit.)
• Flash Point: 158 °F
• Appearance: clear yellow to orange liquid
• Density: 1.378 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0098mmHg at 25°C
• Refractive Index: n20/D 1.461(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform, Methanol
• PKA: 1.98±0.10(Predicted)
• BRN: 1950800
• CAS DataBase Reference: 2-Fluoro-5-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-(trifluoromethyl)aniline(535-52-4)
• EPA Substance Registry System: 2-Fluoro-5-(trifluoromethyl)aniline(535-52-4)

Safety Data

• Hazard Codes: Xn,Xi,T
• Statements: 20/21/22-36/37/38-23-21/22
• Safety Statements: 26-36/37-45-36/37/39
• RIDADR: UN2810/6.1/II
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 535-52-4(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow to orange liquid

Uses

2-Fluoro-5-(trifluoromethyl)aniline may be used in chemical synthesis studies.

InChI:InChI=1/C7HClF4O2/c8-2-3(9)1(7(13)14)4(10)6(12)5(2)11/h(H,13,14)

Upstream product

• 402-44-8 4-Fluorobenzotrifluoride 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 7439-89-6 iron 
• 588-00-1 1,2-bis(3-(trifluoromethyl)phenyl)diazene 
• 98-16-8 3-trifluoromethylaniline 
• 352-32-9 p-fluorotoluene 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 402-42-6 4-fluoro-1-trichloromethylbenzene 

Downstream Products

• 2284-87-9 N-<2-Fluor-5-trifluormethyl-phenyl>-carbamidsaeureisopropylester 
• 58140-17-3 C₁₆H₇F₈N₅ 
• 143925-52-4 N-(2-Fluoro-phenyl)-4-methoxy-benzamide 
• 86844-83-9 (1S,2R,6S,7R)-4-(2-Fluoro-5-trifluoromethyl-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]decane-3,5-dione 
• 87126-67-8 3-(2-Fluoro-5-trifluoromethyl-phenylcarbamoyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid 
• 300561-25-5 N-(2-fluoro-5-trifluoromethylphenyl)methanesulfonamide 
• 260045-47-4 2-chloro-4-(2-fluoro-5-trifluoromethylanilino)pyrimidine 
• 939807-34-8 N-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxa-borolan-2-yl)phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea 
• 325983-98-0 2-chloro-N-(2-fluoro-5-(trifluoromethyl)phenyl)acetamide 
• 871553-48-9 phenyl N-[2-fluoro-5-(trifluoromethyl)phenyl]carbamate 
• 871553-30-9 ethyl 4-amino-5-{4-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenyl}pyrrolo[2,1-f]-[1,2,4]triazine-6-carboxylate 
• 39208-19-0 2-[2-fluoro-5-(trifluoromethyl)anilino]benzoxazole 
• 882678-69-5 N-(2-fluoro-5-(trifluoromethyl)phenyl)-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 691887-41-9 3-Tert-Butyl-5-Chloro-N-(2-Fluoro-5-Trifluoromethyl-Phenyl)-2-Hydroxy-6-Methyl-Benzamide 

Relevant articles and documents

Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination

A detailed mechanism study on the anion ligand promoted selective C-H bond fluorination is reported. The role of the anion ligand has been clarified by experimental evidence and DFT calculations. Moreover, the nitrate promoted C-F bond reductive elimination enabled a selective C-H bond fluorination of various symmetric and asymmetric azobenzenes to access diverse o-fluoroanilines.

Torsional and Electronic Factors Control the C?H???O Interaction

The precise role of non-conventional hydrogen bonds such as the C?H???O interaction in influencing the conformation of small molecules remains unresolved. Here we survey a series of β-turn mimetics using X-ray crystallography and NMR spectroscopy in conju

CYANOMETHYLENE COMPOUNDS, PROCESS FOR PRODUCING THE SAME, AND AGRICULTURAL OR HORTICULTURAL BACTERICIDE

The cyanomethylene compound of the invention is a compound represented by the formula (1) wherein R is C1-20 straight-chain or branched-chain alkyl, C3-8 cycloalkyl, aryl or heterocyclic group; and the aryl and the heterocyclic group