53559-18-5

Basic information

• Product Name: H-TYR-NH2 HCL
• Synonyms: TYROSINE-NH2 HCL;L-TYROSINE AMIDE HYDROCHLORIDE;H-TYR-NH2 HCL;L-Tyrosinamide hydrochloride;Tyr-NH2 HCl;TYR-NH2·HCL 98+%;H-L-Tyr-NH2*HCl;(alphaS)-alpha-Amino-4-hydroxybenzenepropanamide hydrochloride
• CAS NO: 53559-18-5
• Molecular Formula: C₉H₁₂N₂O₂*ClH
• Molecular Weight: 216.66
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 53559-18-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Store at RT.
• CAS DataBase Reference: H-TYR-NH2 HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-TYR-NH2 HCL(53559-18-5)
• EPA Substance Registry System: H-TYR-NH2 HCL(53559-18-5)

Safety Data

• Hazardous Substances Data: 53559-18-5(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline

Upstream product

• 16870-43-2 L-tyrosine hydrochloride 
• 3978-80-1 Boc-Tyr-OH 
• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 60-18-4 L-tyrosine 

Downstream Products

• 60-18-4 L-tyrosine 
• 121637-83-0 NPS-Phe-Tyr-NH₂ 
• 74158-38-6 (S)-2-tert-Butoxycarbonylamino-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 100304-69-6 Boc-Tyr-D-Arg(Tos)-Phe-Gly-Tyr-NH₂ 
• 100304-62-9 H-Tyr-D-Arg-Phe-Gly-Tyr-NH₂ 
• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 80621-91-6 tert-butyloxycarbonyl-sarcosyl-tyrosine amide 
• 80621-93-8 sarcosyl-tyrosine amide trifluoracetate 
• 1150315-18-6 creatinyl-tyrosine amide 
• 1593627-67-8 C₁₇H₂₅ClN₂O₄ 
• 1593627-69-0 C₂₇H₃₃N₄O₄⁽¹⁺⁾*I^(1-) 
• 17263-42-2 benzyl ((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate 
• 74158-36-4 (S)-2-(2-tert-Butoxycarbonylamino-acryloylamino)-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 74158-42-2 (3S,9S,12S)-6-Hydroxy-9-(4-hydroxy-benzyl)-12-isopropyl-3,6-dimethyl-1-oxa-4,7,10-triaza-cyclododecane-2,5,8,11-tetraone 

Relevant articles and documents

α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease

Increased Gram-negative bacteria resistance to antibiotics is becoming a global problem, and new classes of antibiotics with novel mechanisms of action are required. The caseinolytic protease subunit P (ClpP) is a serine protease conserved among bacteria that is considered as an interesting drug target. ClpP function is involved in protein turnover and homeostasis, stress response, and virulence among other processes. The focus of this study was to identify new inhibitors of Escherichia coli ClpP and to understand their mode of action. A focused library of serine protease inhibitors based on diaryl phosphonate warheads was tested for ClpP inhibition, and a chemical exploration around the hit compounds was conducted. Altogether, 14 new potent inhibitors of E. coli ClpP were identified. Compounds 85 and 92 emerged as most interesting compounds from this study due to their potency and, respectively, to its moderate but consistent antibacterial properties as well as the favorable cytotoxicity profile.