53595-99-6

Basic information

• Product Name: Benzenamine, 2-chloro-N-(4-methoxyphenyl)-
• CAS NO: 53595-99-6
• Molecular Formula: C13H12ClNO
• Molecular Weight: 233.697
• Mol File: 53595-99-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenamine, 2-chloro-N-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2-chloro-N-(4-methoxyphenyl)-(53595-99-6)
• EPA Substance Registry System: Benzenamine, 2-chloro-N-(4-methoxyphenyl)-(53595-99-6)

Safety Data

• Hazardous Substances Data: 53595-99-6(Hazardous Substances Data)

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 88-73-3 2-Chloronitrobenzene 
• 95-57-8 2-monochlorophenol 
• 104-94-9 4-methoxy-aniline 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 95-51-2 o-chloroaniline 

Downstream Products

• 501326-35-8 N-benzyl-2-chloro-N-(4-methoxyphenyl)aniline 
• 1257334-80-7 4-(2-chlorophenylimino)cyclohexa-2,5-dienone 
• 18992-85-3 3-methoxycarbazole 

Relevant articles and documents

Visible-Light- And PPh3-Mediated Direct C-N Coupling of Nitroarenes and Boronic Acids at Ambient Temperature

We present here a metal-free, visible-light- and triphenylphosphine-mediated intermolecular, reductive amination between nitroarenes and boronic acids at ambient temperature without any photocatalyst. Mechanistically, a slow reduction of nitroarenes to a nitroso and, finally, a nitrene intermediate occurs that leads to the amination product with concomitant 1,2-aryl/-alkyl migration from a boronate complex. A wide range of nitroarenes underwent C-N coupling with aryl-/alkylboronic acids providing high yields.

A facile C-N bond formation: One-pot reaction of phenols and amines via smiles rearrangement

Diarylamines and arylalkylamines were synthesized in high yields from 2-chlorophenols and amines, activated by chloroacetyl chloride under microwave irradiation (20-60 min) or conventional thermal conditions (3-6 h). The key transformation is believed to

A novel catalytic one-pot synthesis of carbazoles via consecutive amination and C-H activation

Sequential palladium catalysed amination and C-H activation reactions occur between 2-chloro-N-alkylated anilines and aryl bromides to give carbazoles in one pot.