53611-44-2

Basic information

• Product Name: 6-ethyl-2-Piperidinone
• Synonyms: 6-ethyl-2-Piperidinone;6-Tthyl-2-piperidinone;6-Ethylpiperidin-2-one
• CAS NO: 53611-44-2
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.18422
• Mol File: 53611-44-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 266.531 °C at 760 mmHg
• Flash Point: 148.864 °C
• Appearance: /
• Density: 0.931 g/cm³
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.438
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-ethyl-2-Piperidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ethyl-2-Piperidinone(53611-44-2)
• EPA Substance Registry System: 6-ethyl-2-Piperidinone(53611-44-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 53611-44-2(Hazardous Substances Data)

Usage

General Description

6-Ethyl-2-piperidinone is a unique chemical compound that belongs to the class of organic compounds known as piperidinones. Its IUPAC name is Ethyl-2-piperidinone. As a chemical structure, it contains a piperidinone moiety, which is a six-membered saturated ring containing one nitrogen atom, one ketone group, and five carbon atoms. It is utilized as a chemical intermediate in various reactions due to its reactivity. However, its safety, health effects, or environmental impacts are not widely studied and not publicly available, hence caution should be taken in its handling and usage.

InChI:InChI=1/C7H13NO/c1-2-6-4-3-5-7(9)8-6/h6H,2-5H2,1H3,(H,8,9)

Upstream product

• 7664-93-9 sulfuric acid 
• 98435-37-1 2-Ethylcyclopentanone oxime 
• 64847-88-7 2-ethylcyclopentanone 
• 98-09-9 benzenesulfonyl chloride 
• 1121-89-7 piperidine-2,6-dione 
• 925-90-6 ethylmagnesium bromide 
• 1484-80-6 2-ethylpiperidine 

Relevant articles and documents

Direct Catalytic Desaturation of Lactams Enabled by Soft Enolization

A direct catalytic method is described for the α,β-desaturation of N-protected lactams to their conjugated unsaturated counterparts under mildly acidic conditions. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups, showing reactivity complementary to that of prior desaturation methods. Lactams with various ring sizes and substituents at different positions all reacted smoothly. The synthetic utility of this method is demonstrated in a concise synthesis of Rolipram. In addition, linear amides also prove to be competent substrates, and the phthaloyl-protected product serves as a convenient precursor to access various conjugated carboxylic acid derivatives. Strong bases are avoided in this desaturation approach, and the key is to merge soft enolization with a Pd-catalyzed oxidation process.

Pushing radical cyclization from regioselective to regiospecific: Cyclization of amidyl radicals controlled by vinylic halogen substitution

Efficient and regiospecific 6-exo, 7-endo, 7-exo, and even 8-endo amidyl radical cyclizations can be accomplished by the direct reactions of unsaturated N-H amides if they bear a vinylic halogen (Cl, Br, I) substituent. This remarkable halogen-substitution effect could be rationalized in terms of lone pair-lone pair electron repulsion between the N radical and the vinylic halogen atom, in addition to the well-known steric and radical-stabilizing effect.

Liquid phase oxidation of saturated nitrogen-containing heterocyclics over modified MCM-41 molecular sieves

For the first time, the liquid phase oxidation reactions of saturated N-heterocyclics like piperidine and pyrrolidine to piperidone and pyrrolidone have been carried out over modified MCM-41 molecular sieves with 30-55% yield and >80% selectivity.