53663-25-5Relevant articles and documents
Ind2TiMe2-catalyzed addition of methyl- and ethylamine to alkynes
Marcsekova, Klaudia,Wegener, Bernd,Doye, Sven
, p. 4843 - 4851 (2007/10/03)
We describe a very simple hydrogenation-like experimental protocol for the addition of gaseous methyl- and ethylamine to alkynes in the presence of Ind2TiMe2 as the catalyst. For efficient hydroamination reactions it is sufficient to stir a mixture of the alkyne and the catalyst in toluene at temperatures between 80°C (terminal alkynes) and 105°C (internal alkynes) under a constant pressure of 1 atm of the corresponding amine. After subsequent reduction of the initially formed imines, methyl- and ethylamine derivatives are the final products of the described one-pot reaction sequences. In the case of 2-alkyl-1-phenylalkynes as starting materials, biologically interesting 2-phenylethylamine derivatives possessing a small methyl or ethyl substituent at the N atom are easily accessible by the new reaction protocol. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
2-azacyclocarboxamide derivatives
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, (2008/06/13)
Compounds are provided of the following general structure: STR1 wherein A is 2-pyrrolidinyl, 2-piperidinyl or 4-thiazolidinyl and R and R1 are independently selected from hydrogen and methyl. They are useful for providing sedative and antiepile
2-[(2-aminoacetyl)amino]acetamide derivatives
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, (2008/06/13)
Compounds are provided of the following general structure: STR1 wherein R1, R2, R3 and R4 are hydrogen or methyl and where R5 and R6 are independently selected from hydrogen or fluorine. Th
