5369-03-9 Usage
Uses
Different sources of media describe the Uses of 5369-03-9 differently. You can refer to the following data:
1. QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.
2. QX 314 Chloride has been shown to have antitussive properties in mammalian animal models.
Biological Activity
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels.
Biochem/physiol Actions
Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.
Check Digit Verification of cas no
The CAS Registry Mumber 5369-03-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,6 and 9 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5369-03:
(6*5)+(5*3)+(4*6)+(3*9)+(2*0)+(1*3)=99
99 % 10 = 9
So 5369-03-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
