53786-46-2 Usage
Description
Ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine-1-carboxylate is a complex chemical compound that integrates ethyl ester, piperidine, and benzimidazole moieties, with a notable chlorine atom and oxo group within the benzimidazole ring. ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine-1-carboxylate is recognized for its potential biological activities and medicinal properties, positioning it as a candidate for pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
Ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine-1-carboxylate is utilized as a precursor or active pharmaceutical ingredient for the development of new drugs. Its unique structure and functional groups contribute to its potential role in treating various diseases or conditions, although the specific applications and properties require further research and testing to fully understand its therapeutic potential and safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 53786-46-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,7,8 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 53786-46:
(7*5)+(6*3)+(5*7)+(4*8)+(3*6)+(2*4)+(1*6)=152
152 % 10 = 2
So 53786-46-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H18ClN3O3/c1-2-22-15(21)18-7-5-11(6-8-18)19-13-4-3-10(16)9-12(13)17-14(19)20/h3-4,9,11H,2,5-8H2,1H3,(H,17,20)
53786-46-2Relevant articles and documents
Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: Optimization of the 4-substituted piperidine
Burgey, Christopher S.,Stump, Craig A.,Nguyen, Diem N.,Deng, James Z.,Quigley, Amy G.,Norton, Beth R.,Bell, Ian M.,Mosser, Scott D.,Salvatore, Christopher A.,Rutledge, Ruth Z.,Kane, Stefanie A.,Koblan, Kenneth S.,Vacca, Joseph P.,Graham, Samuel L.,Williams, Theresa M.
, p. 5052 - 5056 (2007/10/03)
In our continuing effort to identify CGRP receptor antagonists for the acute treatment of migraine, we have undertaken a study to evaluate alternative 4-substituted piperidines to the lead dihydroquinazolinone 1. In this regard, we have identified the piperidinyl-azabenzimidazolone and phenylimidazolinone structures which, when incorporated into the benzodiazepine core, afford potent CGRP receptor antagonists (e.g., 18 and 29). These studies produced a potent analog (18) which overcomes the instability issues associated with the lead structure 1. A general pharmacophore for the 4-substituted piperidine component of these CGRP receptor antagonists is also presented.
Neuroleptic n-oxacyclyl-alkylpiperidine derivatives
-
, (2008/06/13)
Neuroleptically active compounds of the formula STR1 wherein R6 and R10 are --H or CH3 ; R7 and R8 are independently --H, --F, --Cl, or --CH3 ; and R9 is --F, --Cl, --CH3, or --OCH3.
