5384-57-6

Basic information

• Product Name: 1-(4-HYDROXY-2,3-DIMETHYL-PHENYL)-ETHANONE
• Synonyms: 1-(4-HYDROXY-2,3-DIMETHYL-PHENYL)-ETHANONE
• CAS NO: 5384-57-6
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 5384-57-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 148°C
• Appearance: /
• CAS DataBase Reference: 1-(4-HYDROXY-2,3-DIMETHYL-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-HYDROXY-2,3-DIMETHYL-PHENYL)-ETHANONE(5384-57-6)
• EPA Substance Registry System: 1-(4-HYDROXY-2,3-DIMETHYL-PHENYL)-ETHANONE(5384-57-6)

Safety Data

• Hazardous Substances Data: 5384-57-6(Hazardous Substances Data)

Usage

Preparation

Obtained by Fries rearrangement of 2,3-dimethylphenyl acetate, ? with aluminium chloride, in nitrobenzene at r.t. (50–60%) , in carbon disulfide at r.t. (10%) or without solvent at 100° (17%); ? with titanium tetrachloride without solvent at 100° (6%).

Upstream product

• 22618-22-0 2,3-dimethylphenyl acetate 
• 526-75-0 2,3-Dimethylphenol 
• 75-36-5 acetyl chloride 
• 2944-49-2 2,3-dimethylanisole 
• 41068-27-3 1-(4-methoxy-2,3-dimethyl-phenyl)-ethanone 
• 101536-88-3 3a',6'-diacetyl-3a',4',7',7a'-tetrahydro-3,3,3'',3''-tetramethyldispiro-methano-<1H>-indene-8',2''>oxirane 
• 101536-87-2 3a',5'-diacetyl-3a',4',7',7a'-tetrahydro-3,3,3'',3''-tetramethyldispiro-methano-<1H>-indene-8',2''>oxirane 

Downstream Products

• 97888-86-3 4-benzyloxy-2,3-dimethylacetophenone 
• 51233-76-2 2,4-diacetyl-5,6-dimethylphenol 
• 92864-07-8 (+/-)-3-(4-Acetyl-2,3-dimethyl-phenoxy)-butan-2-on 
• 873325-02-1 2,3-dimethylphenyl-4-[(1S)-1-((1S,4S)-5-{[5-(trifluromethyl)pyridin-2-yl]carbonyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)ethyl]phenol 
• 873324-98-2 1-[4-(allyloxy)-2,3-dimethylphenyl]ethanone 
• 97888-88-5 2-diisopropylamino-1-(4-benzyloxy-2,3-dimethylphenyl)-ethanol hydrochloride 
• 97888-78-3 O-(4-benzyloxy-2,3-dimethylbenzoyl)-ω-hydroxy-4-benzyloxy-2,3-dimethylacetophenone 
• 97900-40-8 2-diisopropylamino-1-(4-hydroxy-2,3-dimethylphenyl)-ethanol hydrochloride 
• 97888-87-4 1-(4-Benzyloxy-2,3-dimethyl-phenyl)-2-diisopropylamino-ethanone 
• 97888-79-4 4-benzyloxy-2,3-dimethyl-ω-bromoacetophenone 
• 41068-27-3 1-(4-methoxy-2,3-dimethyl-phenyl)-ethanone 

Relevant articles and documents

ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES

Aryl-substituted piperazine derivatives are provided. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesti

4-(1-HYDROPEROXY-1-METHYLETHYL)-1,3-CYCLOPENTADIENYL METHYL KETONE: ITS FORMATION FROM α-TERPINEOL AND BEHAVIOR AS A DIMETHYLFULVENE EPOXIDE.

Ozonolysis of α-terpineol (1) then steam distillation in presence of acid gives the known 4-isopropylidenecyclopentenyl methyl ketone (4).This is oxidized in air to 4-(1-hydroperoxy-1-methylethyl)-1,3-cyclopentadienyl methyl ketone (10), a compound frequently reacting as if it were one of the elusive dimethylfulvene epoxides.It is converted by silica gel to two dimers (12, 13) of 2-acetyl-6,6-dimethylfulvene epoxide (19).Catalytic reduction of the dimers occurs mostly by exo addition of hydrogen to the conjugated double bond, and thermolysis of the dimers yields 4-acetyl-6,6-dimethylcyclohexa-2,4-dienone (20).With triphenylphosphine the hydroperoxide (10) yields two dimers of 2-acetyl-6,6-dimethylfulvene (26).This is the first reported isolation of dimers of a fulvene.The hydroperoxide (10) adds diazomethane to give an unstable pyrazoline (28); this pyrazoline loses nitrogen to yield a single isomer o' 5-acetyl-3',3'-dimethylbicyclohex-3-ene-2-spiro-2'-oxirane (29).Catalytic hydrogenation of the latter involves ring opening of the epoxide.