53934-76-2

Basic information

• Product Name: (2-OXOPYRROLIDIN-1-YL)ACETIC ACID
• Synonyms: 2-Pyrrolidinon-1-ylacetic acid;2-(2-ketopyrrolidin-1-yl)acetic acid;2-(2-oxo-1-pyrrolidinyl)acetic acid;2-(2-oxopyrrolidin-1-yl)ethanoic acid;2-(2-oxopyrrolidin-1-yl)acetate;(2-oxopyrrolidin-1-yl)acetic acid(SALTDATA: FREE);Piracetam Impurity 1
• CAS NO: 53934-76-2
• Molecular Formula: C₆H₉NO₃
• Molecular Weight: 143.14
• Mol File: 53934-76-2.mol
• Article Data: 19

Chemical Properties

• Melting Point: 143℃ (benzene )
• Boiling Point: 379.1°C at 760 mmHg
• Flash Point: 183°C
• Appearance: /Solid
• Density: 1.319g/cm³
• Vapor Pressure: 8.56E-07mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.75±0.10(Predicted)
• CAS DataBase Reference: (2-OXOPYRROLIDIN-1-YL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-OXOPYRROLIDIN-1-YL)ACETIC ACID(53934-76-2)
• EPA Substance Registry System: (2-OXOPYRROLIDIN-1-YL)ACETIC ACID(53934-76-2)

Safety Data

• Hazardous Substances Data: 53934-76-2(Hazardous Substances Data)

Usage

Uses

(2-Oxopyrrolidin-1-yl)acetic acid is a reagent in the preparation of pyrazolopyridines as PDE4B inhibitors.

InChI:InChI=1/C6H9NO3/c8-5-2-1-3-7(5)4-6(9)10/h1-4H2,(H,9,10)

Upstream product

• 61516-73-2 2-(oxo-pyrrolidin-1-yl)-acetic acid ethyl ester 
• 616-45-5 2-pyrrolidinon 
• 50-00-0 formaldehyd 
• 201230-82-2 carbon monoxide 
• 79-08-3 bromoacetic acid 
• 59776-89-5 2-(2-oxopyrrolidin-1-yl)acetylhydrazide 
• 59776-90-8 Dupracetam 
• 543-24-8 N-acetylglycine 
• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 497250-66-5 2-(oxo-pyrrolidin-1-yl)-acetic acid tert-butyl ester 
• 143023-95-4 benzyl 2-(1'-aza-2'-oxocyclopentyl)ethanoate 
• 142274-08-6 (4-ethoxy-1,5-dihydro-2-oxo-2H-pyrrol-1-yl)acetic acid 
• 105-36-2 ethyl bromoacetate 
• 59776-88-4 methyl-2-oxopyrrolidine-1-acetate 

Downstream Products

• 6908-67-4 (E)-1-(2-phenylethenyl)-2-pyrrolidinone 
• 62563-06-8 dimethyl 2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate 
• 64026-55-7 ((2-oxo-1-pyrrolidinyl)acetamido)cetamide 
• 1075715-78-4 1-{2-[8-Fluoro-1-oxo-3-((S)-1-phenyl-propylamino)-1H-isochromen-4-yl]-2-oxo-ethyl}-pyrrolidin-2-one 
• 1190615-41-8 tert-butyl (2R,5S)-2-[(R)-hydroxy(pyridin-3-yl)methyl]-5-(4-{[(2-oxopyrrolidin-1-yl)acetyl]amino}benzyl)pyrrolidine-1-carboxylate trifluoroacetate 
• 73193-59-6 diethyl 3-oxopiperidine-1,4-dicarboxylate 
• 774605-29-7 3-(2,6-dichloro-phenyl)-5-(2-oxo-pyrrolidin-1-ylmethyl)-isoxazole-4-carboxylic acid ethyl ester 
• 774605-53-7 3-(2,6-dichloro-phenyl)-5-(2-oxo-pyrrolidin-1-ylmethyl)-isoxazole-4-carboxylic acid 

Relevant articles and documents

Synthesis of N-Lauroyl Sarcosine by Amidocarbonylation: Comparing Homogeneous and Heterogeneous Palladium Catalysts

An improved system for the synthesis of N-acyl amino acids via Pd-catalyzed amidocarbonylation is reported. Utilizing inexpensive Pd black gives the industrially important surfactant N-lauroyl sarcosine in excellent yields (95%) on a multi-gram scale. Advantages of the new system include reusability, decreased process temperature, and, importantly, drastically decreased co-catalyst loading.

ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS

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Facile synthesis of gold icosahedra in an aqueous solution by reacting HAuCl4 with N-vinyl pyrrolidone

Herein we describe a protocol that generates Au icosahedra in high yields by simply mixing aqueous solutions of HAuCl4 and N-vinyl pyrrolidone. Our mechanistic study reveals that water plays an important role in this synthesis: as a nucleophile