53976-65-1

Basic information

• Product Name: 2,3-Dichloropyridine 1-oxide
• Synonyms: 2,3-Dichloropyridine 1-oxide;2,3-Dichloropyridine N-oxide;2,3-dichloro-1-oxidopyridin-1-ium
• CAS NO: 53976-65-1
• Molecular Formula: C₅H₃Cl₂NO
• Molecular Weight: 163.99
• Product Categories: pharmacetical
• Mol File: 53976-65-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -1.49±0.10(Predicted)
• CAS DataBase Reference: 2,3-Dichloropyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dichloropyridine 1-oxide(53976-65-1)
• EPA Substance Registry System: 2,3-Dichloropyridine 1-oxide(53976-65-1)

Safety Data

• Hazardous Substances Data: 53976-65-1(Hazardous Substances Data)

Usage

General Description

2,3-Dichloropyridine 1-oxide is a chemical compound with the molecular formula C5H3Cl2NO. It is a pale yellow crystalline solid that is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The compound is a potent inhibitor of cytochrome P450 enzymes and has been studied for its potential therapeutic applications in treating cancer and other diseases. However, it is also considered to be toxic and harmful if ingested or inhaled, and proper precautions should be taken when handling and using this chemical.

InChI:InChI=1/C5H4Cl2NO/c6-4-2-1-3-8(9)5(4)7/h1-3,9H

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 

Downstream Products

• 1240248-19-4 (R)-3-chloro-2-(3-methylpiperazin-1-yl)pyridine 1-oxide 

Relevant articles and documents

Nature of the Nucleophilic Oxygenation Reagent Is Key to Acid-Free Gold-Catalyzed Conversion of Terminal and Internal Alkynes to 1,2-Dicarbonyls

2,3-Dichloropyridine N-oxide, a novel oxygen transfer reagent, allows the conductance of the gold(I)-catalyzed oxidation of alkynes to 1,2-dicarbonyls in the absence of any acid additives and under mild conditions to furnish the target species, including those derivatized by highly acid-sensitive groups. The developed strategy is effective for a wide range of alkyne substrates such as terminal- and internal alkynes, ynamides, alkynyl ethers/thioethers, and even unsubstituted acetylene (40 examples; yields up to 99%). The oxidation was successfully integrated into the trapping of reactive dicarbonyls by one-pot heterocyclization and into the synthesis of six-membered azaheterocycles. This synthetic acid-free route was also successfully applied for the total synthesis of a natural 1,2-diketone.

Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor

A series of 2-pyridone-containing imidazoline derivatives was synthesized and evaluated as neuropeptide Y Y5 receptor antagonists. Optimization of the 2-pyridone structure on the 2-position of the imidazoline ring led to identification of 1-(difluoromethy