54016-70-5

Basic information

• Product Name: 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide
• Synonyms: 3-ETHYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM BROMIDE;Atorvastatin Intermediate;3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium Bromlde;Thiazolium, 3-ethyl-5-(2-hydroxyethyl)-4-methyl-, bromide;3-ETHYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM BROM;3-ETHYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM BROMIDE 98+%;3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazole bromide;3-Ethyl-4-methyl-5-(2-hydroxyethyl)thiazole-3-ium·bromide
• CAS NO: 54016-70-5
• Molecular Formula: Br*C₈H₁₄NOS
• Molecular Weight: 252.17
• EINECS: 258-925-2
• Product Categories: Chemical intermediate for Atorvastatin Calcium;Greener Alternatives: Catalysis;Heterocyclic Ammonium Salts;Phase Transfer Catalysts
• Mol File: 54016-70-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 82-87 °C(lit.)
• Appearance: White/Crystalline Powder
• Storage Temp.: Store below +30°C.
• Water Solubility: very faint turbidity
• BRN: 4165775
• CAS DataBase Reference: 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide(54016-70-5)
• EPA Substance Registry System: 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide(54016-70-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 54016-70-5(Hazardous Substances Data)

Usage

Chemical Properties

Brown solid

Uses

3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide is used in the novel synthesis of benzoin catalyzed by thiazolium salts.

Upstream product

• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 74-96-4 ethyl bromide 

Downstream Products

• 134169-11-2 1-<3-(methylthio)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione 
• 125971-96-2 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide 
• 670749-34-5 1-[3-methoxy-4-hydroxy-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)-butane-1,4-dione 
• 73627-36-8 1,2-bis[4-(trifluoromethyl)phenyl]-2-hydroxyethanone 
• 1394043-87-8 2-(4-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-4H-1,4-thiazin-6-yl)ethyl benzoate 
• 1394043-86-7 4-ethyl-6-(2-hydroxyethyl)-5-methyl-2-phenyl-2,3-dihydro-4H-1,4-thiazin-3-one 
• 513-86-0 3-hydroxy-2-butanon 

Relevant articles and documents

Acetoin synthesis method

The invention provides an acetoin synthesis method. The method comprises 1, catalyst preparation: mixing 4-methyl-5-beta-hydroxyethyl thiazole (I) and bromoethane according to a mole ratio of 1: 1, carrying out heating reflux in an acetoin solvent in an oil bath for a reaction, then carrying out stirring cooling to the room temperature, carrying out rotary evaporation, recovering the solvent, standing the white precipitates, carrying out suction filtration and washing, carrying out acetoin recrystallization and carrying out drying to obtain a catalyst 3-ethyl-4-methyl-5-hydroxyethyl thiazole bromide (II) and 2, carrying out acetaldehyde condensation to obtain acetoin, adding the catalyst 3-ethyl-4-methyl-5-hydroxyethyl thiazole bromide (II) into an acetaldehyde solution, adjusting pH to 9-10, carrying out heating stirring for a condensation reaction in a pressure reactor until the pressure in the pressure reactor is 0 MPa, mixing the reaction solution, the recovered solvent and solutions collected in standing, suction filtration and washing processes, and carrying out reduced pressure distillation to obtain acetoin (III).

Methods of Treating or Preventing Cardiac Disease Associated With a High Fat Diet

The present invention relates to a method of treating or preventing cardiac disorders, myocardial inflammation or myocardial oxidative stress associated with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention. The present invention also relates to a method of ameliorating weight gain, myocardial AGE accumulation associated, mitochondrial superoxide production, RAGE expression or PPARα expression with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention.

Method for treating fibrotic diseases or other indications IC

Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: