5407-87-4Relevant articles and documents
Synthesis method of 2-amino-4,6-dimethylpyridine
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Paragraph 0021-0022; 0026-0033; 0037-0043, (2020/07/15)
The invention discloses a synthesis method of 2-amino-4,6-dimethylpyridine. The synthesis method is characterized by comprising the following steps: adding 3-aminocrotononitrile into acetic acid in batches, and carrying out heating for ripening; cooling a reaction liquid, and beginning to decompress and concentrate acetic acid; then adding a concentrated solution into crushed ice, and carrying outsuction filtration, suspension washing and drying on a separated solid to obtain an intermediate; adding the intermediate into a concentrated sulfuric acid solution, and carrying out heating for ripening; carrying out cooling, and dropwise adding pure water for a quenching reaction; pouring a reaction liquid obtained in the previous step into crushed ice, then adding methylbenzene for extractionmultiple times, combining upper-layer organic phases, and sequentially performing washing with saturated sodium chloride, drying, suction filtration and concentration to obtain a crude product; carrying out reduced-pressure solid distillation on the crude product, and collecting a product fraction; and recrystallizing the obtained fraction by using isopropyl ether so as to obtain the white crystalline 2-amino-4,6-dimethylpyridine. According to the prepared high-purity 2-amino-4,6-dimethyl pyridine, GC purity can reach 99% or above, and total yield is 70% or above.
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
Hagmann,Caldwell,Chen,Durette,Esser,Lanza,Kopka,Guthikonda,Shah,MacCoss,Chabin,Fletcher,Grant,Green,Humes,Kelly,Luell,Meurer,Moore,Pacholok,Pavia,Williams,Wong
, p. 1975 - 1978 (2007/10/03)
A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM.
