54075-25-1

Basic information

• Product Name: BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)-
• Synonyms: BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)-;2,2,2-Trichloro-1-(4-nitrophenyl)ethanol
• CAS NO: 54075-25-1
• Molecular Formula: C₈H₆Cl₃NO₃
• Molecular Weight: 270.49714
• Mol File: 54075-25-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 93-94 °C(Solv: carbon tetrachloride (56-23-5); ligroine (8032-32-4))
• Boiling Point: 385.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.624±0.06 g/cm3(Predicted)
• PKA: 11.18±0.20(Predicted)
• CAS DataBase Reference: BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)-(54075-25-1)
• EPA Substance Registry System: BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)-(54075-25-1)

Safety Data

• Hazardous Substances Data: 54075-25-1(Hazardous Substances Data)

Usage

General Description

BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)-, also known as triclosan, is a chemical compound used as an antimicrobial agent in a variety of consumer products such as soaps, toothpaste, and deodorants. Triclosan has been found to be effective in killing a wide range of bacteria and fungi, making it a popular ingredient in personal care and household products. However, there is growing concern about the potential negative impact of triclosan on human health and the environment, leading to restrictions on its use in certain countries. Studies have shown that triclosan may disrupt hormones, contribute to antibiotic resistance, and have harmful effects on aquatic organisms when it enters water systems. As a result, there is ongoing research and debate about the safety and regulation of triclosan in consumer products.

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 619-73-8 4-nitrobenzyl chloride 
• 67-66-3 chloroform 
• 100-52-7 benzaldehyde 
• 650-51-1 sodium trichloroacetate 
• 76-03-9 trichloroacetic acid 
• 75-62-7 Bromotrichloromethane 
• 2000-43-3 2,2,2-trichloro-1-phenylethanol 

Downstream Products

• 34006-49-0 2-chloro-1-(4-nitrophenyl)ethanone 
• 16208-23-4 2,2‐dichloro‐1‐(4‐nitrophenyl)ethan‐1‐one 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 104-03-0 4-nitrobenzeneacetic acid 
• 10098-39-2 2-hydroxy-2-(4-nitrophenyl)acetic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 4714-32-3 1-nitro-4-(1,2,2,2-tetrachloro-ethyl)-benzene 
• 117389-29-4 2-Amino-3-cyano-5-(4-nitro-phenyl)-4-oxo-cyclopent-2-enecarboxylic acid ethyl ester 
• 5281-22-1 1-(2,2-dichlorovinyl)-4-nitrobenzene 
• 1620143-51-2 ethyl [2,2,2-trichloro-1-(4-nitrophenyl)ethyl]carbonate 

Relevant articles and documents

The Decomposition of Trihalogenoacetic Acids in Dimethyl Sulphoxide: a Mild Route from Carbonyl Compounds to Trihalogenomethylethanols and Trihalogenomethyl Ketones

Solutions of trichloro- and tribromo-acetic acid in dimethyl sulphoxide in the presence of carbonyl compounds react at room temperature to give isolable products corresponding to the addition of H-CX3 across the carbonyl double bond.

A novel β-(oxy)alkyl radical during copper(I)-mediated stereoselective synthesis of (Z)-ene-1,4-diones in a reaction of 2,2,2-trichloro-1-phenylethanone

A novel β-(oxy)alkyl radical derived from trichloro methyl compound containing neither a suitably located C-C multiple bond nor a leaving group or a H-atom at the β-position of the radical in a reaction of 2,2,2-trichloro-1-phenyl-ethanone with 2 mol equiv each of CuCl and bpy in refluxing DCE under a N2 atm underwent intramolecular heterolysis (just like formation of intact radical cation-anion pair) during stereoselective radical dimerization to Z-ene-1,4-dione along with small amount of reductive dechlorination product. The stereochemistry was established by X-ray diffraction spectroscopy of various solid crystalline products.

Decarboxylative trichloromethylation of aromatic aldehydes and its applications in continuous flow

Two new protocols for the efficient synthesis of 2,2,2- trichloromethylcarbinols, starting from aromatic aldehydes, have been developed. A combination of sodium trichloroacetate in the presence of malonic acid proved efficient for the transformation of el