541-59-3Relevant articles and documents
Preparation method of maleimide
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Paragraph 0061; 0066-0069; 0070; 0075-0078, (2022/03/27)
The invention provides a preparation method of maleimide, which comprises the following steps: S1, reacting maleic anhydride with p-methoxybenzylamine to generate 3-(4-methoxybenzylamino) acrylic acid; step S2, enabling the 3-(4-methoxybenzyl carbamoyl) acrylic acid to react with acetic anhydride, so as to generate 1-(4-methoxybenzyl) maleimide; and S3, removing the 1-(4-methoxybenzyl) group from the 1-(4-methoxybenzyl) maleimide under the action of an oxidizing agent, so as to generate the maleimide. The preparation method provided by the embodiment of the invention has the advantages of short experimental route, high raw material safety, strong experimental operability and suitability for industrial production.
METHOD OF PRODUCING MALEIMIDE
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Paragraph 0019, (2020/09/24)
PROBLEM TO BE SOLVED: To provide a method of producing an aliphatic maleimide using substantially no solvent capable of avoiding various problems caused by solvent vapor, and securing good environmental compatibility where the A-MI obtained by the method is useful as a laminate material, an encapsulating material, an electrically insulating material, a conductive paste, an adhesive, a tackiness agent, a structural material and the like. SOLUTION: The method of producing an aliphatic maleimide comprises reacting an aliphatic amine with more than 1.2 equivalent of maleic anhydride and/or maleic acid to 1 equivalent of the aliphatic amine using no solvent substantially. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
Catalyst and Additive-Free Diastereoselective 1,3-Dipolar Cycloaddition of Quinolinium Imides with Olefins, Maleimides, and Benzynes: Direct Access to Fused N,N′-Heterocycles with Promising Activity against a Drug-Resistant Malaria Parasite
Kumar, Rakesh,Chaudhary, Sandeep,Kumar, Rohit,Upadhyay, Pooja,Sahal, Dinkar,Sharma, Upendra
, p. 11552 - 11570 (2018/09/25)
A convenient and eco-friendly synthesis of various fused N-heterocyclic compounds through catalyst and additive-free 1,3 dipolar cycloadditions of quinolinium imides with olefins, maleimides, and benzynes in excellent yields and diastereoselectivities is reported. The thermally controlled diastereoselective [3 + 2] cycloaddition reaction between quinolinium imides and olefins provided cis-isomers at low temperature and trans-isomers at high temperature. A reaction between quinolinium imides with substituted maleimides gave four-ring-fused N-heterocyclic compounds in high yields as a single diastereomer. The aryne precursors also provided four-ring-fused N,N′-heterocyclic compounds in high yields. The in vitro antiplasmodial activity of selected molecules revealed that this class of molecules possesses potential for ongoing studies against malaria.