5410-10-6

Basic information

• Product Name: (ACETYL-METHOXYCARBONYLMETHYL-AMINO)-ACETIC ACID METHYL ESTER
• Synonyms: N-Acetyl-iminodiacetic acid methyl ester;(ACETYL-METHOXYCARBONYLMETHYL-AMINO)-ACETIC ACID METHYL ESTER
• CAS NO: 5410-10-6
• Molecular Formula: C₈H₁₃NO₅
• Molecular Weight: 203.19
• Mol File: 5410-10-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 304.9 °C at 760 mmHg
• Flash Point: 138.2 °C
• Appearance: /
• Density: 1.181 g/cm³
• CAS DataBase Reference: (ACETYL-METHOXYCARBONYLMETHYL-AMINO)-ACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (ACETYL-METHOXYCARBONYLMETHYL-AMINO)-ACETIC ACID METHYL ESTER(5410-10-6)
• EPA Substance Registry System: (ACETYL-METHOXYCARBONYLMETHYL-AMINO)-ACETIC ACID METHYL ESTER(5410-10-6)

Safety Data

• Hazardous Substances Data: 5410-10-6(Hazardous Substances Data)

Usage

General Description

(Acetyl-methoxycarbonylmethyl-amino)-acetic acid methyl ester, also known as AMMAME, is a chemical compound with a complex molecular structure. It is a methyl ester derivative of acetyl-methoxycarbonylmethyl-amino-acetic acid, which is a synthetic peptide. AMMAME is used in pharmaceutical research and development as a building block for the synthesis of various drug molecules. It has potential applications in the field of medicinal chemistry, and its unique structure may contribute to its ability to interact with biological targets. Additionally, its methyl ester group may also play a role in modulating its chemical properties and biological activity. Overall, AMMAME is a valuable chemical entity that can be utilized in the creation of new drug candidates and may offer insights into the design of novel therapeutic agents.

Upstream product

• 6096-81-7 dimethyl iminodiacetate 
• 108-24-7 acetic anhydride 
• 39987-25-2 dimethyl iminodiacetate hydrochloride 

Downstream Products

• 2234-38-0 3,4-bis(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid 
• 1632-49-1 3,4-diphenyl-1H-pyrrole-2,5-dicarboxylic acid 

Relevant articles and documents

N-Acetyliminodiacetate dimethyl ester

N-Acetyliminodiacetate dimethyl ester, C8H13NO5, was prepared for the synthesis of 3,4-diphenylpyrrole in a multi-step synthetic route to a model porphyrin. The technique used in this preparation yielded colorless crystals of high purity. Site geometry around the central N atom is nearly trigonal planar.

Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors

The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. In this work, we designed and synthesized neolamellarin A and its series of derivatives by a convergent synthetic strategy. The HIF-1 inhibitory activity and cytotoxicity of these compounds were evaluated in Hela cells by dual-luciferase reporter gene assay and MTT assay, respectively. The results showed that neolamellarin A 1 (IC50 = 10.8 ± 1.0 μM) and derivative 2b (IC50 = 11.9 ± 3.6 μM) had the best HIF-1 inhibitory activity and low cytotoxicity. Our SAR research focused on the effects of key regions aliphatic carbon chain length, aromatic ring substituents and C-7 substituent on biological activity, providing a basis for the subsequent research on the development of novel pyrrole alkaloids as HIF-1 inhibitors and design of small molecule probes for target protein identification.

Synthesis of 1',2',3',4',5'-pentamethyl-3,4-diphenylazaferrocene and its enantioselective C-2 functionalization via (-)-sparteine-mediated lithiation

Lithiation of 1',2',3',4',5'-pentamethyl-3,4-diphenylazaferrocene (9) with sec-BuLi/(-)-sparteine (2) in Et2O at -78 °C followed by quenching with electrophiles gave the C-2 functionalized azaferrocenes (17) in good enantioselectivities (up to