5417-35-6Relevant articles and documents
Stereocontrolled Route to 2,3,5-Trisubstituted Tetrahydrofurans. Intermediates for the Total Synthesis of Polyether Antibiotics.
Frauenrath, Herbert,Runsink, Jan
, p. 2707 - 2712 (1987)
The stereoselective synthesis of diastereomers of 2,3,5-trisubstituted tetrahydrofurans has been accomplished by Lewis acid catalyzed acetal rearrangement.The reaction sequence starts with 4,7-dihydro-1,3-dioxepins 4, which are isomerized to 4,5-dihydro-1,3-dioxepins 6.The key step of the procedure is the stereocontrolled rearrangement of these mixed alkyl vinyl acetals 6, followed by reduction. 2,3,5-Trisubstituted tetrahydrofurans are of general interest for the synthesis of polyether antibiotics.
Synthesis and cytotoxic properties of some cyclic acetals of diols and their dichlorocyclopropyl derivatives
Raskil’dina,Kuzmina, U. Sh.,Dzhumaev, Sh. Sh.,Borisova, Yu. G.,Ishmetova,Vakhitova, Yu. V.,Zlotskii
, p. 475 - 478 (2021/04/09)
Cyclic acetals of ethylene glycol, cis-but-2-ene-1,4-diol and their dichlorocyclopropyl derivatives were synthesized. Compounds simultaneously containing the gem-dichlorocyclopropane and 1,3-dioxacycloalkane cycles are shown to exhibit cytotoxic activity against the HEK293, SH-SY5Y, HepG2, MCF-7, A549, and Jurkat cell lines. The obtained results open up prospects for further studies of antitumor activity of 2-(2,2-dichlorocyclopropyl)-2-ethyl-1,3-dioxolane.
Monofunctional metathesis polymers via sacrificial diblock copolymers
Hilf, Stefan,Berger-Nicoletti, Elena,Grubbs, Robert H.,Kilbinger, Andreas F. M.
, p. 8045 - 8048 (2007/10/03)
(Chemical Equation Presented) A small price to pay: The second block of a diblock copolymer is "sacrificed" in order to leave behind a monofunctionalized metathesis polymer with a hydroxy end group. By incorporation of a dioxepine unit into the copolymer, a breaking point is created between the block to be end-functionalized and the block to be sacrificed.