54177-02-5

Basic information

• Product Name: 3-(2-METHOXY-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER
• Synonyms: 3-(2-METHOXY-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER;AKOS BBS-00002639;Methyl 3-(2-methoxyphenyl)-3-oxopropanoate;Methyl 3-(2-Methoxyphenyl)-3-oxopropionate
• CAS NO: 54177-02-5
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.21
• Mol File: 54177-02-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 291.7 °C at 760 mmHg
• Flash Point: 125.4 °C
• Appearance: /
• Density: 1.147 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 10.22±0.46(Predicted)
• CAS DataBase Reference: 3-(2-METHOXY-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-METHOXY-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER(54177-02-5)
• EPA Substance Registry System: 3-(2-METHOXY-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER(54177-02-5)

Safety Data

• Hazardous Substances Data: 54177-02-5(Hazardous Substances Data)

Usage

Uses

Methyl 3-(2-Methoxyphenyl)-3-oxopropanoate is a reactant that has been used in the synthesis of indanonecarboxylates in a catalytic Nazarov reaction.

Upstream product

• 579-74-8 2-Methoxyacetophenone 
• 616-38-6 carbonic acid dimethyl ester 
• 118-93-4 o-hydroxyacetophenone 
• 79-20-9 acetic acid methyl ester 
• 606-45-1 2-methoxybenzoic acid methyl ester 

Downstream Products

• 579-74-8 2-Methoxyacetophenone 
• 1159586-51-2 C₁₃H₁₆O₄ 
• 1202873-86-6 C₂₂H₂₄N₄O₄ 
• 1202873-74-2 C₂₂H₂₃N₃O₅ 
• 862588-78-1 C₁₁H₁₂N₂O₂ 

Relevant articles and documents

Chiral Vanadyl(V) Complexes Enable Efficient Asymmetric Reduction of β-Ketoamides: Application toward (S)-Duloxetine

High-valent chiral oxidovanadium(V) complexes derived from 3,5-substituted-N-salicylidene-l-tert-leucine were used as catalysts in asymmetric reduction of N-benzyl-β-ketoamides. Among six different solvents, three different alcohol additives, and two different boranes examined, the use of pinacolborane in tetrahydrofuran (THF) with a t-BuOH additive led to the best results at -20 °C. The corresponding β-hydroxyamides can be furnished with yields up to 92percent and an enantiomeric excess (ee) up to 99percent. We have successfully extended this catalytic protocol for the synthesis of an (S)-duloxetine precursor.

Geminal Dichlorination of Phenyliodonium Ylides of β-Dicarbonyl Compounds through Double Ligand Transfer from (Dichloroiodo)benzene

Pre-formed phenyliodonium ylides of cyclic and acyclic β-diketones, β-keto esters and β-diesters were reacted with (dichloroiodo)benzene, resulting in transfer of both chloride ligands onto the ylidic carbon. These two hypervalent iodine(III) compounds exhibit high reactivity towards each other under mild reaction conditions and typically afford the gem-dichloride products in good yield. Upon comparison of these chlorination reactions with those of the analogous diazocarbonyl compounds, reactions of iodonium ylides were unilaterally faster, and often gave the products in higher yield.

Trimethylchlorosilane-Mediated Mild α-Chlorination of 1,3-Dicarbonyl Compounds Promoted by Phenyliodonium Diacetate

Trimethylchlorosilane was used as chlorine source for the α-chlorination of 1,3-dicarbonyl compounds with phenyliodonium diacetate as oxidant at room temperature. The reaction allows the selective synthesis of α-monochlorinated products from different kinds of 1,3-dicarbonyl compounds in good yield. The potential possibility of this conversion for bromination has also been investigated.