5418-94-0

Basic information

• Product Name: 2-a)pyrimidin-4-one,2-chloro-4h-pyrido(
• Synonyms: 2-a)pyrimidin-4-one,2-chloro-4h-pyrido(;2-Chloro-4H-pyrido[1,2-a]pyrimidin-4-one;2-chloropyrido[1,2-a]pyrimidin-4-one
• CAS NO: 5418-94-0
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.594
• Mol File: 5418-94-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 287°Cat760mmHg
• Flash Point: 127.3°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0.00256mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-a)pyrimidin-4-one,2-chloro-4h-pyrido((CAS DataBase Reference)
• NIST Chemistry Reference: 2-a)pyrimidin-4-one,2-chloro-4h-pyrido((5418-94-0)
• EPA Substance Registry System: 2-a)pyrimidin-4-one,2-chloro-4h-pyrido((5418-94-0)

Safety Data

• Hazardous Substances Data: 5418-94-0(Hazardous Substances Data)

Usage

Uses

2-Chloro-4h-pyrido[1,2-a]pyrimidin-4-one is useful in the synthesis of pyrimidin-5-one derivatives.

InChI:InChI=1/C8H5ClN2O/c9-6-5-8(12)11-4-2-1-3-7(11)10-6/h1-5H

Upstream product

• 237742-94-8 (2-pyridyl)iminopropadienone 
• 27420-41-3 2-hydroxy-4H-pyrido<1,2-a>pyrimidin-4-one 
• 138305-21-2 ethyl 3-oxo-3-(pyridin-2-ylamino)propianoate 
• 504-29-0 2-aminopyridine 
• 123419-89-6 2-Methylthio-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carboxylic acid 
• 84292-17-1 2-(dimethylamino)-4H-pyrido<1,2-a>pyrimidin-4-one 
• 22288-66-0 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione 
• 10025-87-3 trichlorophosphate 
• 111680-69-4 2-chloro-N-phenyl-4H-pyrido<1,2-a>pyrimidin-4-imine 

Downstream Products

• 84292-23-9 2-(diethylamino)-4H-pyrido<1,2-a>pyrimidin-4-one 
• 237742-94-8 (2-pyridyl)iminopropadienone 
• 1220910-27-9 4-imino-2-(methylthio)-5-oxo-1-phenyl-1,5-dihydro-4H-dipyrido-[1,2-a:2',3'-d]pyrimidine-3-carbonitrile 
• 16054-93-6 2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1335239-80-9 2-(2'-acetylphenyl)-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1335239-84-3 2-benzyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1335239-79-6 2-[4-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-4-one 
• 191218-37-8 2-(4'-methoxyphenyl)-4H-pyrido[1,2-a]pyrimidin-4-one 
• 111680-78-5 2-(phenylamino)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde 
• 154816-49-6 2-(4-methyl-1-piperazinyl)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde 
• 111692-71-8 2-(phenylamino)-4H-pyrido<1,2-a>pyrimidin-4-one 
• 17481-62-8 2-chloro-4-oxo-4H-pyrido<1,2-a>pyrimidine 3-carboxaldehyde 
• 17326-31-7 2-morfolino-4H-pirido<1,2-a>pirimidin-4-one 
• 55395-30-7 2-hydrazinyl-4H-pyrido[1,2-a]pyrimidin-4-one 

Relevant articles and documents

QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF

Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

(2-Pyridyl)iminopropadienone

(2-Pyridyl)iminopropadienone 13 is generated by flash vacuum thermolysis (FVT) of 2-substituted pyrido[1,2-a]pyrimidin-4-ones 9 and observed by IR spectroscopy. Addition of HCl to 13 causes reversion to the starting material 9b, whereas addition of nucleophiles leads to malonic acid imide derivatives (23, 24, 26, 27, 28). The latter undergo thermal elimination of amines to regenerate 2-substituted pyridopyrimidinones. A competing retro-ene reaction occurs on FVT of 2-(dialkylamino)pyridopyrimidinones 9c,d, presumably in the oxoketenimine intermediates 22/25, with formation of the unsubstituted pyridopyrimidinone 31.