5424-03-3

Basic information

• Product Name: (2E)-3-(2-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
• CAS NO: 5424-03-3
• Molecular Formula: C₁₆H₁₃ClO₂
• Molecular Weight: 272.7262
• Mol File: 5424-03-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 427.4°C at 760 mmHg
• Flash Point: 172.3°C
• Density: 1.207g/cm³
• Vapor Pressure: 1.64E-07mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: (2E)-3-(2-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(2-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one(5424-03-3)
• EPA Substance Registry System: (2E)-3-(2-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one(5424-03-3)

Safety Data

• Hazardous Substances Data: 5424-03-3(Hazardous Substances Data)

Usage

General Description

The chemical compound with the IUPAC name "(2E)-3-(2-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one" is a derivative of prop-2-en-1-one containing a 2-chlorophenyl group and a 4-methoxyphenyl group. It is also known as 2-chloro-1-(4-methoxyphenyl)-3-(2-propenylidene)cyclohexan-1-one. (2E)-3-(2-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one is a yellow crystalline solid with a molecular formula of C16H13ClO2 and a molecular weight of 274.72 g/mol. It is commonly used as a reagent in organic synthesis and has potential applications in pharmaceutical research and the development of new drugs. The compound may also have biological activities and pharmacological properties that are of interest to researchers.

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 1777-55-5 (4-methoxyphenacylidene)triphenyl phosphorane 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1234670-69-9 1-(2-chlorophenyl)-3-(4-methoxyphenyl)-3-oxopropyl diethylcarbamodithioate 
• 1058744-66-3 (S)-2-((R)-1-(2-chlorophenyl)-3-(4-methoxyphenyl)-3-oxopropyl)-cyclohexanone 

Relevant articles and documents

New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors

Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazoline structure and nine compounds having N′-(1,3-disubstitutedphenylallylidene)-2-(5-substituted-2-benzoxazolinone-3-yl)acetohydrazide skeleton wer

Enantioselective Copper-Catalyzed 1,5-Cyanotrifluoromethylation of Vinylcyclopropanes

A copper-catalyzed enantioselective 1,5-cyanotrifluoromethylation of vinylcyclopropanes has been developed using a radical relay strategy. This asymmetric reaction has demonstrated high enantioselective control, broad substrate scope, and mild conditions. Initiated by the in situ generated CF3 radical from Togni's reagent, this method offers a new solution for remote enantioselective bifunctionalization of alkenes and thus provides a straightforward way for the synthesis of chiral CF3-containing internal alkenylnitriles.

An eco-friendly synthesis of 2-pyrazoline derivatives catalysed by CeCl 3· 7 H 2O

Abstract: 1,3,5-triaryl-2-pyrazoline derivatives were synthesised by a condensation reaction between chalcones and phenyl hydrazine using cerium chloride heptahydrate as a catalyst. All these reactions were carried out in ethyl lactate (70%) as a green solvent. Easy and efficient work up, recyclability of solvent and catalyst are the key merits of this protocol. Graphical Abstract:: SYNOPSIS A facile protocol for the synthesis of 1,3,5-triaryl-2-pyrazolines is described. The solvent ethyl lactate, obtained from renewable sources, is biodegradable. The catalyst CeCl 3· 7 H 2O is a water-tolerant Lewis acid with low toxicity. Easy and clean work up, recyclable solvent and catalyst are merits of the protocol. The reaction works well for all systems giving good yields of the desired products.[Figure not available: see fulltext.].