54264-96-9Relevant articles and documents
Benzylic oxidation of aromatics with cerium(IV) triflate; Synthetic scope and mechanistic insight
Laali, Kenneth K.,Herbert, Mark,Cushnyr, Brad,Bhatt, Anand,Terrano, David
, p. 578 - 583 (2007/10/03)
The synthetic utility of cerium(IV) triflate Ce(OTf)4 as a reagent for benzylic oxidation has been tested for a variety of aromatic compounds. Insight is provided into various factors that govern these oxidations and their progress. It has been shown that the mode of preparation of Ce(OTf)4 and the % H2O present in the sample have a marked influence on oxidation ability. A variety of mono- and dialkylbenzenes, haloalkylbenzenes, bicyclic and tricyclic ring systems, and alkoxybenzenes have been surveyed. The method offers an easy to perform one-pot reaction for the room temperature synthesis of aromatic ketones and aldehydes from aromatics and has the potential to find wider application.