54322-41-7

Basic information

• Product Name: AC-SER-OME
• Synonyms: AC-SER-OME;AC-SERINE-OME;ACETYL-L-SERINE METHYL ESTER;N-ALPHA-ACETYL-L-SERINE METHYL ESTER;N-ACETYL-L-SERINE METHYL ESTER;N-Acetylserine methyl ester;(S)-Methyl 2-acetaMido-3-hydroxypropanoate;N-Ac-L-Ser-OMe
• CAS NO: 54322-41-7
• Molecular Formula: C₆H₁₁NO₄
• Molecular Weight: 161.16
• Mol File: 54322-41-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 376.3 °C at 760 mmHg
• Flash Point: 181.4 °C
• Appearance: /
• Density: 1.194 g/cm³
• Vapor Pressure: 3.33E-07mmHg at 25°C
• Refractive Index: 1.457
• Storage Temp.: -15°C
• PKA: 13.83±0.10(Predicted)
• CAS DataBase Reference: AC-SER-OME(CAS DataBase Reference)
• NIST Chemistry Reference: AC-SER-OME(54322-41-7)
• EPA Substance Registry System: AC-SER-OME(54322-41-7)

Safety Data

• Hazardous Substances Data: 54322-41-7(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow syrup

Uses

Ac-ser-ome can be used to treat cardiovascular disease and bone disease.

InChI:InChI=1/C6H11NO4/c1-4(9)7-5(3-8)6(10)11-2/h5,8H,3H2,1-2H3,(H,7,9)

Upstream product

• 15028-41-8 methyl 2-aminoisobutyrate hydrochloride 
• 75-36-5 acetyl chloride 
• 2788-84-3 (S)-serine methyl ester 
• 581-55-5 benzylidene 1,1-diacetate 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 903566-73-4 [1S,2S,6S,7S]-1,6-diaza-4,9-dioxa-2,7-dimethoxycarbonylbicyclo[4.4.1]undecane 
• 64-19-7 acetic acid 
• 186581-53-3 diazomethane 
• 16354-58-8 N-acetyl-L-serine 
• 2104-89-4 Ser-OMe 
• 108-24-7 acetic anhydride 
• 1068-84-4 2-aminomalonic acid 
• 55299-55-3 N-Acetyl-3-O-p-tolylsulfonyl-DL-serin-methylester 

Downstream Products

• 57289-21-1 (S)-methyl 2-acetamido-3-(formyloxy)propanoate 
• 16354-58-8 N-acetyl-L-serine 
• 175481-26-2 2-acetamido-N-benzyl-3-methoxypropionamide 
• 171514-07-1 (+)-2-acetamido-3-azidopropanoic acid methyl ester 
• 5429-56-1 N-Acetamidoacrylic acid 
• 97-14-3 N-acetyl-serine 
• 171623-02-2 (R,S)-N-acetylserine-N-benzylamide 
• 7652-46-2 2-acetylamino-3-mercapto-propionic acid methyl ester 
• 464-72-2 tetraphenylethane-1,2-diol 

Relevant articles and documents

Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine

Three human G protein-coupled receptors (GPCRs)—GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3—are activated specifically by lysophosphatidylserine (LysoPS), an endogenous hydrolysis product of a cell membrane component, phosphatidylserine (PS). LysoPS consists of-serine, glycerol, and fatty acid moieties connected by phosphodiester and ester linkages. We previously generated potent and selective GPCR agonists by modification of the three modules and the ester linkage. Here, we show that a novel modification of the hydrophilic serine moiety, that is, N-acylations of the serine amine, converted a GPR174 agonist to potent GPR174 antagonists. Structural exploration of the amide functionality provided access to a range of activities from agonist to partial agonist to antagonist. The present study would provide a new strategy for the development of lysophospholipid receptor antagonists.

Synthesis method and application of 1-aza -5-germanium-5-alkyl bicyclic [3.3.3] undecane compound.

The invention provides a 1-aza-5-germanium hetero-5-alkyl bicyclic [3.3.3] hendecane compound having a structure shown in the formula I, and the types of the 1-aza-5-germanium hetero-5-alkyl bicyclic[3.3.3] hendecane compound are expanded. The provided compound can serve as a nucleophilic reagent, the air and humidity conditions of the nucleophilic reagent are stable, and the efficiency of the Ge-Stille coupling reaction of aryl halogen and the 1-aza-5-germanium hetero-5-alkyl bicyclic [3.3.3] hendecane compound is high.

1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines

1,1-Diacyloxy-1-phenylmethanes and 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as bench stable N-acylating reagents for primary and secondary amines and anilines under solvent-free conditions to afford their corresponding amides in good yield.