5437-26-3

Basic information

• Product Name: 1-(3-nitrophenyl)-2-(quinolin-2-yl)ethanol
• CAS NO: 5437-26-3
• Molecular Formula: C₁₇H₁₄N₂O₃
• Molecular Weight: 294.3047
• Mol File: 5437-26-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 459°C at 760 mmHg
• Flash Point: 231.4°C
• Density: 1.335g/cm³
• Vapor Pressure: 3.22E-09mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 1-(3-nitrophenyl)-2-(quinolin-2-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-nitrophenyl)-2-(quinolin-2-yl)ethanol(5437-26-3)
• EPA Substance Registry System: 1-(3-nitrophenyl)-2-(quinolin-2-yl)ethanol(5437-26-3)

Safety Data

• Hazardous Substances Data: 5437-26-3(Hazardous Substances Data)

Usage

General Description

1-(3-nitrophenyl)-2-(quinolin-2-yl)ethanol, also known as NQETH, is a chemical compound that consists of a nitrophenyl group and a quinolin-2-yl group attached to a central ethanol molecule. It is a member of the family of ethanolamines, which are commonly used as building blocks in organic synthesis. NQETH has potential applications in medicinal chemistry as it possesses both anti-inflammatory and antioxidant properties. Its molecular structure also suggests that it may have biological activity as a potential pharmaceutical agent. Additionally, the presence of the nitro group in the compound may contribute to its ability to undergo reduction reactions, which are useful in the synthesis of a variety of molecules.

Upstream product

• 91-63-4 2-methylquinoline 
• 619-25-0 3-Nitrobenzyl alcohol 
• 99-61-6 3-nitro-benzaldehyde 

Relevant articles and documents

α-Chymotrypsin–catalyzed direct C (Sp3)–H functionalization reactions for synthesis of azaarene derivatives in water

α-Chymotrypsin from the bovine pancreas has been shown for the first time to display catalytic nonnatural catalytic ability toward the C (sp3)–H functionalization reaction of 2-methylquinoline and aromatic aldehydes in water. α-Chymotrypsin exhibited favorable catalytic activity with good adaptability to different substrates. The activity of the enzyme could be improved by adjusting the solvent, temperature, molar ratio of substrates, and protein loading. The products were obtained in moderate to excellent yields (51%-93%) in 24 samples. This process afforded a potential biocatalytic approach as an alternative to chemical synthesis for azaarene derivatives.

A synthesis method of pyridine and quinoline derivatives

The invention discloses a method for synthesizing pyridine and quinoline derivative. The method for synthesizing the pyridine and quinoline derivative comprises the following steps: heating and carrying out reaction on a pyridine or quinoline compound A and an aldehyde compound B in an ionic liquid [Bmim]BF4, wherein an ionic liquid [Hnhm]HSO4 is taken as a catalyst, and pyridine and quinoline derivative C can be obtained after reaction is carried out for a period of time. The catalyst [Hmim]H2PO4 and the solvent [Bmim]BF4 which are used in the reaction can be recycled and utilized for eight times, and yield of a final product is not obviously reduced; therefore, the method for synthesizing the pyridine and quinoline derivative can reduce experimental cost to the utmost extent and reduce environmental pollution and has a good application prospect. The reaction formula is described in the specification.

Acid ionic liquid promoted addition of C(sp3)-H bond to aldehyde

A novel protocol for acid ionic liquid promoted C(sp3)-H bond functionalization of alkyl azaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields, which provides an efficient approach for the synthesis of alkyl-substituted azaarene derivatives. It is worthwhile to note that acid ionic liquid used for this reaction can be recycled and reused six times without a significant decrease in activity.