5440-67-5

Basic information

• Product Name: 1-(2-methyl-2-nitro-propyl)-4-nitro-benzene
• Synonyms: 1-(2-methyl-2-nitro-propyl)-4-nitro-benzene;2-NITRO-2-(4-NITROBENZYL)PROPANE
• CAS NO: 5440-67-5
• Molecular Formula: C₁₀H₁₂N₂O₄
• Molecular Weight: 224.21
• Mol File: 5440-67-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 373.8°C at 760 mmHg
• Flash Point: 180.2°C
• Appearance: /
• Density: 1.246g/cm³
• Vapor Pressure: 8.76E-06mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 1-(2-methyl-2-nitro-propyl)-4-nitro-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methyl-2-nitro-propyl)-4-nitro-benzene(5440-67-5)
• EPA Substance Registry System: 1-(2-methyl-2-nitro-propyl)-4-nitro-benzene(5440-67-5)

Safety Data

• Hazardous Substances Data: 5440-67-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 105, p. 90, 1983 DOI: 10.1021/ja00339a016Tetrahedron Letters, 18, p. 3063, 1977

InChI:InChI=1/C10H12N2O4/c1-10(2,12(15)16)7-8-3-5-9(6-4-8)11(13)14/h3-6H,7H2,1-2H3

Upstream product

• 79-46-9 2-nitropropane 
• 61081-34-3 methyl 4-nitrobenzylsulfone 
• 3958-63-2 lithium 2-nitropropane 
• 100-14-1 4-nitrobenzyl chloride 
• 83365-34-8 1-(4-nitro-benzyl)-2,4,6-triphenylpyridinium tetrafluoroborate 
• 24163-39-1 sodium 2-nitropropane 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 51392-53-1 4-nitrobenzyl methyl sulfide 
• 141-52-6 sodium ethanolate 

Downstream Products

• 51131-55-6 4-(β-amino-isobutyl)-aniline 
• 1012-18-6 β,β-dimethyl-p-nitrostyrene 
• 79886-12-7 1-(p-aminophenyl)-2-methyl-2-propylamine dihydrochloride 
• 116760-99-7 4-(2-Methyl-propenyl)-phenylamine 
• 116760-98-6 4-(2-methyl-2-nitropropyl)aniline 
• 51202-95-0 2-(4-aminocyclohexyl)-1,1-dimethylethylamine 
• 122-09-8 Phentermin 
• 56490-93-8 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine hydrochloride 
• 77890-09-6 DL-iodoazidobenzylpindolol 
• 81530-23-6 1,1-dimethyl-2-(4-amino-3-iodophenyl)ethylamine 
• 81530-24-7 1,1-dimethyl-2-(4-azido-3-iodophenyl)ethylamine 
• 101639-67-2 1-<4-(2-cyclopropylmethoxyethyl)phenoxy>-3-<1-p-(aminophenyl)-2-methyl-2-propylamine>-2-propanol 

Relevant articles and documents

Further evidence for the effect of ultrasonic waves on electron transfer processes - The case of the Kornblum-Russell reaction

The Kornblum-Russell action is directly influenced by sonication. Under optimal conditions of irradiation, the ratio of C/O alkylation is practically reversed with respect to that of the silent reaction, indicating a direct intervention of sonic waves in the electron transfer process.

CCR10 ANTAGONISTS

The invention relates to a compound of formula (I) or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various diseases and disorders in a patient. The invention also relates to processes for preparing the compounds of formula (I) and intermediates useful in these processes.

Tandem Hass-Bender/Henry reaction for the synthesis of dimethylnitro alcohols from benzylic halides

Dimethylnitro alcohols are constructed in a one-pot process from benzylic halides and 2-nitropropane. The use of tetrabutylammonium fluoride (TBAF) as the promoter is essential for this tandem Hass-Bender/Henry reaction to proceed.