5441-52-1Relevant articles and documents
Preparation method of cis, cis-3, 5-dimethyl-1-cyclohexanol
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Paragraph 0091-0093; 0094-0099, (2020/08/18)
The invention belongs to the field of chemistry, and discloses a synthesis method of a cis, cis-3, 5-dimethyl-1-cyclohexanol compound shown as a formula (I). Acetaldehyde and ethyl acetoacetate are used as raw materials, and cis, cis-3, 5-dimethyl-1-cyclohexanol is synthesized by a series of reactions such as knoevenagel condensation, hydrolysis, decarboxylation, hydrogenation reduction, reduction, acylating chlorination, hydrolysis and the like. The raw materials and auxiliary materials of the route are simple and easily available, the reaction conditions are mild, the operation is simple andconvenient, the synthesis cost is low, and the obtained product has high chiral purity (the product/isomer ratio is 30: 1-100: 1) and is suitable for large-scale production.
Selective Catalytic Hydrogenation of Arenols by a Well-Defined Complex of Ruthenium and Phosphorus-Nitrogen PN3-Pincer Ligand Containing a Phenanthroline Backbone
Li, Huaifeng,Wang, Yuan,Lai, Zhiping,Huang, Kuo-Wei
, p. 4446 - 4450 (2017/07/24)
Selective catalytic hydrogenation of aromatic compounds is extremely challenging using transition-metal catalysts. Hydrogenation of arenols to substituted tetrahydronaphthols or cyclohexanols has been reported only with heterogeneous catalysts. Herein, we demonstrate the selective hydrogenation of arenols to the corresponding tetrahydronaphthols or cyclohexanols catalyzed by a phenanthroline-based PN3-ruthenium pincer catalyst.
Phosphine effects in the copper(I) hydride-catalyzed hydrogenation of ketones and regioselective 1,2-reduction of α,β-unsaturated ketones and aldehydes. Hydrogenation of decalin and steroidal ketones and enones
Chen, Jian-Xin,Daeuble, John F.,Stryker, Jeffrey M.
, p. 2789 - 2798 (2007/10/03)
The stereoselectivity and regioselectivity of the catalytic hydrogenation of ketones and α,β-unsaturated ketones and aldehydes using soluble copper(I) hydride catalysts have been investigated as a function of the ancillary phosphine ligand. While a relatively narrow range of aryldialkylphosphine ligands produce active hydrogenation catalysts, some ligands provide higher selectivity for 1,2-reduction of acyclic unsaturated carbonyl substrates than observed using the previously reported dimethylphenylphosphine-stabilized catalyst. The synthetic utility of this class of hydridic hydrogenation catalysts is illustrated by the hydrogenation of decalin and steroidal ketones and enones, the latter giving allylic alcohols with high selectivity. (C) 2000 Elsevier Science Ltd.
