54444-99-4

Basic information

• Product Name: 6-CHLORO-CHROMAN-3-YLAMINE HYDROCHLORIDE
• Synonyms: 6-CHLORO-CHROMAN-3-YLAMINE HYDROCHLORIDE
• CAS NO: 54444-99-4
• Molecular Formula: C9H11Cl2NO
• Molecular Weight: 220.09574
• Mol File: 54444-99-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-CHLORO-CHROMAN-3-YLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-CHROMAN-3-YLAMINE HYDROCHLORIDE(54444-99-4)
• EPA Substance Registry System: 6-CHLORO-CHROMAN-3-YLAMINE HYDROCHLORIDE(54444-99-4)

Safety Data

• Hazardous Substances Data: 54444-99-4(Hazardous Substances Data)

Usage

Common Use

Pharmaceutical research and development

Derivative

Chroman-3-ylamine group with chlorine atom at 6-position of chroman ring

Salt Form

Hydrochloride to improve solubility and stability in aqueous solutions

Biological Activities

Studied for potential use in treatment of diseases and conditions

Building Block

Used for synthesis of other pharmaceutical compounds

Upstream product

• 18518-71-3 (R)-chroman-3-amine hydrochloride 
• 916223-21-7 (R)-N-(chroman-3-yl)-2,2,2-trifluoroacetamide 
• 916223-22-8 (R)-N-(6-chlorochroman-3-yl)-2,2,2-trifluoroacetamide 

Relevant articles and documents

NOVEL HETEROAROMATIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME

A compound selectively inhibiting Nav1.7 over Nav1.5 is provided. A heteroaromatic amide derivative or salt thereof showing high efficacy for various diseases associated with Nav1.7 such as pain, represented by the general formula (I) [wherein, X1-X2 is N-C or C-N, Y1 , Y2, Y3 and Y4 are -CH2-, -CR4aH- or -O- and so on, Z1 is-O- and so on, ring A is a 3- to 7-membered monocyclic aromatic ring and so on, R1a and R1b are a hydrogen atom or a halogen atom and so on, R2 is a hydrogen atom and so on, R3a, R3b and R3c are a hydrogen atom or an optionally substituted C1-C6 haloalkyl group and so on, R4a, R4b and R4c are, an optionally substituted C1-C6 haloalkyl group or C1-C6 haloalkoxy group and so on, R5a is a hydrogen atom and so on, R5a and R5b together form -CH2O- and so on, R6a and R6b are a hydrogen atom and so on, n is 1 or 2.].