54533-11-8

Basic information

• Product Name: 1-Chloro-3-methanesulfonyl-propane
• Synonyms: 1-Chloro-3-methanesulfonyl-propane;1-chloro-3-(Methylsulfonyl)propane;3-(Methylsulfonyl)propyl chloride
• CAS NO: 54533-11-8
• Molecular Formula: C₄H₉ClO₂S
• Molecular Weight: 157
• Mol File: 54533-11-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 135-136 °C(Press: 2.7 Torr)
• Appearance: /
• Density: 1.233±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Chloro-3-methanesulfonyl-propane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-3-methanesulfonyl-propane(54533-11-8)
• EPA Substance Registry System: 1-Chloro-3-methanesulfonyl-propane(54533-11-8)

Safety Data

• Hazardous Substances Data: 54533-11-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 19, p. 1583, 1989 DOI: 10.1080/00397918908051054

InChI:InChI=1S/C4H9ClO2S/c1-8(6,7)4-2-3-5/h2-4H2,1H3

Upstream product

• 109-70-6 1.3-chlorobromopropane 
• 5188-07-8 sodium thiomethoxide 
• 126526-58-7 1-chloro-3-methylsulfinylpropane 
• 13012-59-4 3-methylthiopropyl chloride 

Downstream Products

• 1426425-97-9 N-(1-(tertbutyldimethylsilyloxy)-2-methylpropan-2-yl)-2-(6-fluoro-1-(3-(methylsulfonyl)propyl)-1Hindazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 
• 1426425-83-3 N-tert-butyl-2-(6-fluoro-1-(3-(methylsulfonyl)propyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 
• 1242419-30-2 trans-4-{4-[8-(3-methanesulfonyl-propoxy)-imidazo[1,2-a]pyridine-3-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester 

Relevant articles and documents

HETEROCYCLIC INHIBITORS OF GLUTAMINASE

The invention relates to the heterocyclic compounds of Formula (I) as defined further herein, and pharmaceutical preparations thereof. The invention further relates to methods of treating cancer, immunological or neurological diseases using the heterocyclic compounds of the invention.

ANODIC OXIDATION OF 1,n-HALO(ALKYLTHIO)ALKANES AND 1,n-CHLORO(ALKYLSULFINYL)ALKANES

Anodic oxidation of 1,n-halo(alkylthio)alkanes n-S-R, X=Cl, Br, I> and 1,n-halo(alkylsulfinyl)alkanes n-S(O)-R> was studied by cyclic voltammetry in anhydrous acetonitrile and by controlled potential electrolyses.The ease of sulfur oxidation was not affected by the alkyl substituents R or the number of methylene groups n in compounds with n>2.The oxidation of the 1,2-halo(alkylthio)ethanes (n=2) occurred at slightly higher potentials.The peak potentials decreased slightly in the order Cl>Br>I which is probably due to the electronegativity of the halogen atoms.The investigated anodic oxidation was shown to be a two electron irreversible process.Electrolyses in aqueous acetonitrile led to the corresponding sulfoxides and sulfones in good yields.