54588-96-4

Basic information

• Product Name: Benzene, 1-(bromomethyl)-4-(phenylmethyl)-
• CAS NO: 54588-96-4
• Molecular Formula: C14H13Br
• Molecular Weight: 261.161
• Mol File: 54588-96-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(bromomethyl)-4-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(bromomethyl)-4-(phenylmethyl)-(54588-96-4)
• EPA Substance Registry System: Benzene, 1-(bromomethyl)-4-(phenylmethyl)-(54588-96-4)

Safety Data

• Hazardous Substances Data: 54588-96-4(Hazardous Substances Data)

Upstream product

• 623-24-5 1,4-bis(bromomethyl)benzene 
• 98-80-6 phenylboronic acid 
• 32752-54-8 4-(bromomethyl)benzophenone 
• 50-00-0 formaldehyd 
• 101-81-5 Diphenylmethane 
• 100-39-0 benzyl bromide 
• 17100-68-4 2-((4-bromobenzyl)oxy)tetrahydro-2H-pyran 
• 35714-20-6 4-benzylbenzyl alcohol 
• 1027413-28-0 2-(4-Benzyl-benzyloxy)-tetrahydro-pyran 

Downstream Products

• 669774-15-6 2-[(4-benzyl-benzyl)-hydroxy-phosphinoylmethyl]-4-p-tolyl-butyric acid ethyl ester 
• 669774-13-4 2-[(4-benzyl-benzyl)-hydroxy-phosphinoylmethyl]-4-m-tolyl-butyric acid ethyl ester 
• 669774-02-1 2-[(4-benzyl-benzyl)-hydroxy-phosphinoylmethyl]-4-(4-fluoro-phenyl)-butyric acid ethyl ester 
• 669774-17-8 2-[(4-benzyl-benzyl)-hydroxy-phosphinoylmethyl]-4-(4-bromo-phenyl)-butyric acid ethyl ester 
• 669771-01-1 2-[(4-benzyl-benzyl)-hydroxy-phosphinoylmethyl]-4-(2-fluoro-phenyl)-butyric acid ethyl ester 
• 669774-16-7 2-[(4-benzyl-benzyl)-hydroxy-phosphinoylmethyl]-4-(4-chloro-phenyl)-butyric acid ethyl ester 
• 669774-06-5 2-[(4-benzyl-benzyl)-hydroxy-phosphinoylmethyl]-4-o-tolyl-butyric acid ethyl ester 
• 669774-01-0 2-[(4-benzyl-benzyl)-hydroxy-phosphinoylmethyl]-4-(3-fluoro-phenyl)-butyric acid ethyl ester 
• 669774-19-0 2-[(4-benzyl-benzyl)-hydroxy-phosphinoylmethyl]-4-(4-methoxy-phenyl)-butyric acid ethyl ester 

Relevant articles and documents

Microwave-promoted palladium catalysed Suzuki cross-coupling reactions of benzyl halides with arylboronic acid

Simple catalytic systems for the coupling of benzyl halides with phenylboronic acid under microwave conditions were tested. Microwave-promoted Suzuki reaction of arylboronic acid with benzyl halides catalysed by PdCl2(PPh3)2 in the mixed solvents DMF/H2O is reported to give diaryl methane derivatives in good to high yield.

Method for preparing coupling arene from aryl halide by ionizing, discharging and coupling

The invention discloses a method for preparing coupling arene from aryl halide by ionizing, discharging and coupling. The method comprises the following steps: placing a magnetic stirrer into a three-necked flask and adding aryl halide occupying 1/2 flask, thereby finishing the assembling of an ionizing reaction device; placing the ionizing reaction device into an oil bath pan, introducing inert gas into a reaction system, removing air from the reaction system, starting stirring and heating in the oil bath pan to make aryl halide flow back, and meanwhile, introducing water into a ball-shaped condensation pipe for cooling; starting a high-voltage power generator, and introducing powerful arc generated into the three-necked flask through a metal electrode, thereby ionizing and decomposing aryl halide steam and generating a coupling arene compound; stopping ionizing and heating when solids are separated or the backflow of aryl halide is slowed in a round-bottom flask, and then ending the reaction; recrystallizing or performing reduced pressure distillation purification on the coupling arene product in the flask, thereby acquiring the coupling arene product. The method disclosed by the invention has the advantages of low cost, high efficiency, environmental protection, and the like.

PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES

A compound of the formula wherein R1, R2, R3, R4, R5, R6 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, synergy with cytotoxic anticancer agents, tissue ulceration, macular dege