5460-70-8

Basic information

• Product Name: 1,3-diethoxypropan-2-one
• Synonyms: 1,3-Diethoxyacetone; 2-propanone, 1,3-diethoxy-
• CAS NO: 5460-70-8
• Molecular Formula: C₇H₁₄O₃
• Molecular Weight: 146.1843
• Mol File: 5460-70-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 204.9°C at 760 mmHg
• Flash Point: 67.9°C
• Density: 0.949g/cm³
• Vapor Pressure: 0.257mmHg at 25°C
• Refractive Index: 1.408
• CAS DataBase Reference: 1,3-diethoxypropan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-diethoxypropan-2-one(5460-70-8)
• EPA Substance Registry System: 1,3-diethoxypropan-2-one(5460-70-8)

Safety Data

• Hazardous Substances Data: 5460-70-8(Hazardous Substances Data)

Usage

Chemical family

Beta-keto esters

Physical state

Colorless, flammable liquid

Odor

Fruity

Uses

a. Solvent
b. Precursor for the synthesis of various organic compounds
c. Production of pharmaceuticals
d. Production of fragrances
e. Production of agrochemicals
f. Preparation of dyes and pigments
g. Manufacturing of flavorings and perfumes
h. Building block in organic synthesis

Reactivity

Versatile in forming carbon-carbon bonds

Safety precautions

a. Handle with care due to flammability
b. Can cause skin and eye irritation

Upstream product

• 4043-59-8 1,3-diethoxy-isopropanol 
• 141-52-6 sodium ethanolate 
• 534-07-6 1,3-Dichloroacetone 

Downstream Products

• 4043-59-8 1,3-diethoxy-isopropanol 
• 7795-99-5 1-ethoxy-2-ethoxymethyl-3-phenyl-propan-2-ol 

Relevant articles and documents

Scope and limitations of the double [4+3]-cycloadditions of 2-oxyallyl cations to 2,2′-methylenedifuran and derivatives

The reactivity of various 2-oxyallyl cations toward 2,2′-methylenedifuran (1b), 2,2′-(hydroxymethyl)-difuran (1c), 2,2′-(trimethylsilylmethylene)difuran (1d), and di(2-furyl)methanone (1e) has been explored. Difuryl derivatives 1c, 1d, and 1e refused to undergo formal double [4+3]-cycloadditions. Conditions have been found to convert 1b into meso-1,1′-methylenedi[(1R,1′S,5S,5′R)-(3) and (±)-1,1′-methylenedi[(1RS,1′SR,5SR,5′RS)- 8-oxabicyclo[3.2.1]oct-6-en-3-one] (4) that do not require CF3CH(OH)CF3 as solvent. High yields of meso-1,1′-methylenedi[(1R,1′S,2S,2′R,4R,4′S, 5S,5′R)- (5) and (±).1,1′-methylenedi[(1RS,1′RS,2SR,2′SR, 4RS,4′RS,5SR,5′SR)-2,4-dimethyl-8-oxabicyclo[3.2.1]oct-6- en-3-one] (6) have been obtained when 1b was reacted with 2,4-dibromopentan-3-one (7h) and NaI/Cu.

Synthesis of 2,5-dihydrofurans via alkylidene carbene insertion reactions

The insertion of vinylidene carbenes into C-H bonds is an efficient method for the synthesis of 2,5-dihydrofurans. The methodology provides a convenient entry to the core structure of squalestatin/zaragozic acid natural products.