54605-80-0

Basic information

• Product Name: 4-benzoyl-2-hydroxy-2,5-diphenyl-1,2-dihydro-3H-pyrrol-3-one
• CAS NO: 54605-80-0
• Molecular Weight: 355.393
• Mol File: 54605-80-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzoyl-2-hydroxy-2,5-diphenyl-1,2-dihydro-3H-pyrrol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzoyl-2-hydroxy-2,5-diphenyl-1,2-dihydro-3H-pyrrol-3-one(54605-80-0)
• EPA Substance Registry System: 4-benzoyl-2-hydroxy-2,5-diphenyl-1,2-dihydro-3H-pyrrol-3-one(54605-80-0)

Safety Data

• Hazardous Substances Data: 54605-80-0(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 120-46-7 1,3-diphenylpropanedione 
• 80012-16-4 3-amino-1,3-diphenyl-2-propene-1-onate 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 4636-16-2 iodoacetophenone 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 

Relevant articles and documents

Iodine-Promoted Formal [3+2] Cycloaddition of Enaminone: Access to 2-Hydroxy-1,2-dihydro-pyrrol-3-ones with Quaternary Carbon Center

A novel iodine promoted cyclization of enaminone with aryl methyl ketones has been developed as a straightforward method for constructing 2-hydroxy-pyrrol-3(2H)-ones. This strategy affords structurally diverse 2-hydroxy-pyrrol-3(2H)-ones rings in high yields. Moreover, a quarternary alcohol has been constructed efficiently in the reaction. Product purification required only washing with CH2Cl2 solvent, thereby avoiding traditional chromatography and recrystallization, making this an example of group-assisted purification chemistry.