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54610-70-7

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54610-70-7 Usage

Description

2-AMIDINOTHIOPHENE HYDROCHLORIDE is a hydrochloride salt of 2-amidinothiophene, a derivative of thiophene, commonly used in pharmaceutical and research applications. It exhibits antiviral and antiproteinase activity, making it a potential candidate for drug development. Additionally, it serves as a reagent in organic synthesis, particularly in the preparation of heterocyclic compounds, and has been investigated for its potential use in treating respiratory diseases.

Uses

Used in Pharmaceutical Development:
2-AMIDINOTHIOPHENE HYDROCHLORIDE is used as a potential drug candidate for its antiviral and antiproteinase activity, offering therapeutic benefits in the treatment of various diseases.
Used in Organic Synthesis:
In the field of organic synthesis, 2-AMIDINOTHIOPHENE HYDROCHLORIDE is used as a reagent, particularly for the preparation of heterocyclic compounds, contributing to the development of novel chemical entities.
Used in Respiratory Disease Treatment:
2-AMIDINOTHIOPHENE HYDROCHLORIDE is used as a potential therapeutic agent in treating respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD), due to its potential effects on respiratory conditions.
Used in Research Applications:
In research settings, 2-AMIDINOTHIOPHENE HYDROCHLORIDE is utilized for its antiviral and antiproteinase properties, aiding in the study and understanding of disease mechanisms and the development of new treatment strategies.

Check Digit Verification of cas no

The CAS Registry Mumber 54610-70-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,6,1 and 0 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 54610-70:
(7*5)+(6*4)+(5*6)+(4*1)+(3*0)+(2*7)+(1*0)=107
107 % 10 = 7
So 54610-70-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2S.ClH/c6-5(7)4-2-1-3-8-4;/h1-3H,(H3,6,7);1H

54610-70-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name thiophene-2-carboximidamide,hydrochloride

1.2 Other means of identification

Product number -
Other names 2-AMIDINOTHIOPHENE HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:54610-70-7 SDS

54610-70-7Relevant articles and documents

Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide

Lu, Xiaodong,Xin, Xiaoyi,Wan, Boshun

supporting information, p. 361 - 364 (2018/01/08)

A silver-catalyzed [3+2+1] annulation of amidines with benzyl isocyanide toward 2,4-diaryl-1,3,5-triazines was developed. A variety of symmetrical and unsymmetrical products were obtained in moderate to good yields. This work also features an oxidant-free approach to 2,4-disubstituted triazines.

HETEROCYCLIC COMPOUND

-

Paragraph 0546, (2016/09/26)

The problem of the present invention is to provide a compound having a PDE2A inhibitory action, and useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents

Zhang, Nan,Ayral-Kaloustian, Semiramis,Nguyen, Thai,Hernandez, Richard,Lucas, Judy,Discafani, Carolyn,Beyer, Carl

experimental part, p. 111 - 118 (2011/02/25)

The synthesis and SAR of a series of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents are described. This series of 2-heteroarylpyrimidines was developed by modifying a series of anti-tumor [1,2,4]triazolo[1,5-a]pyrimidines and 2-cyanoaminopyrimidines we reported earlier. For the 2-heteroaryl group, the best activity is obtained when the heteroaryl group has a nitrogen atom at the ortho-position to the pyrimidyl core. The structure-activity relationship for the rest of the molecule in this 2-heteroarylpyrimidine series mimics that of the [1,2,4]triazolo[1,5-a]pyrimidine series. Like triazolopyrimidines and 2-cyanoaminopyrimidines, the 2-heteroarylpyrimidines retain the capability to overcome multidrug resistance due to Pgp. Mechanism of action studies showed that the lead compounds behaved in the same manner as triazolopyrimidines and 2-cyanoaminopyrimidines. The lead compounds in this series are more potent than the corresponding triazolopyrimidines in vitro and in vivo. Compound 21 (PTI-868) showed tumor growth inhibition in several nude mouse xenograft models, and was selected to advance to preclinical development.

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