5466-93-3

Basic information

• Product Name: N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester
• Synonyms: 1,4-Bis(ethoxycarbonylamino)benzene;1,4-Phenylenebis(carbamic acid ethyl) ester;N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester
• CAS NO: 5466-93-3
• Molecular Formula: C₁₂H₁₆N₂O₄
• Molecular Weight: 252.2664
• Mol File: 5466-93-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 195-196 °C
• Boiling Point: 299°Cat760mmHg
• Flash Point: 134.7°C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 0.00122mmHg at 25°C
• Refractive Index: 1.585
• PKA: 13.02±0.70(Predicted)
• CAS DataBase Reference: N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester(5466-93-3)
• EPA Substance Registry System: N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester(5466-93-3)

Safety Data

• Hazardous Substances Data: 5466-93-3(Hazardous Substances Data)

Usage

General Description

N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester is a chemical compound with the molecular formula C12H16N2O4. It is an ethyl ester derivative of N-(4-aminophenyl)carbamic acid, and it is commonly used in organic synthesis and pharmaceutical research. N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester has been studied for its potential antimicrobial and antifungal properties, and it has also been investigated as a potential inhibitor of certain enzymes. Additionally, N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester may have applications in the development of new drugs and therapies for various medical conditions. However, its specific uses and potential side effects have not been extensively studied, and further research is needed to fully understand its properties and potential applications.

InChI:InChI=1/C12H16N2O4/c1-3-17-11(15)13-9-5-7-10(8-6-9)14-12(16)18-4-2/h5-8H,3-4H2,1-2H3,(H,13,15)(H,14,16)

Upstream product

• 64-17-5 ethanol 
• 104-49-4 1,4-diisocyanatobenzene 
• 701-56-4 4-methoxy-N,N-dimethylanilne 
• 116015-90-8 N,N'-bisethoxycarbonyl-p-benzoquinone diimine 
• 75-00-3 chloroethane 
• 124-38-9 carbon dioxide 
• 106-50-3 1,4-phenylenediamine 
• 75-03-6 ethyl iodide 
• 17351-61-0 tetraethylammonium bicarbonate 
• 100-21-0 terephthalic acid 
• 121-69-7 N,N-dimethyl-aniline 
• 698-69-1 4-chloro-N,N-dimethylaniline 
• 6628-07-5 N-allyl-N-methylaniline 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 511530-09-9 ethyl N-{[2-(phthalimidomethyl)-4-ethoxycarbonylamino]phenyl}carbamate 
• 101421-72-1 6-amino-quinazoline 
• 29557-85-5 1,4-bis(semicarbazide-4-yl)benzene 
• 1303947-03-6 C₂₁H₁₇⁽²⁾H₄N₃O₆ 
• 67199-66-0 batracylin 
• 945972-17-8 diethyl N,N'-(2-nitro-1,4-phenylene)dicarbamate 
• 104-49-4 1,4-diisocyanatobenzene 
• 106-50-3 1,4-phenylenediamine 

Relevant articles and documents

Sustainable Carboxylation of Diamines with Hydrogen Carbonate

A protocol for the carboxylation of diamines employing quaternary ammonium hydrogen carbonates as C1 source is presented. The approach is used to obtain industrially relevant bis-O-alkyl carbamates with diverse structural features in very high yield, even on gram scale. The quaternary ammonium salts, formally acting as "transporters" of the carboxylating agent, can be recovered after the reaction, and recycled with high efficiency. Regeneration of the hydrogen carbonates on ion-exchange resin grants excellent atom economy in the process.

New metal complexes of semicarbazones derived from para phenylene diamine of NOO/or NO donor sites and their antimicrobial screening

THE SYNTHESIS and characterization of new Mn(II). Co(II). Ni(II) and Cu(II) complexes with semicarbazone ligands derived from para phenylene diamine {where L1 = Semicarbazide-4-yl-benzene-4 (2-hydroxybenzalde-hydc semicarbazone) [SBHBS], L

A new access to quinazolines from simple anilines

A new synthetic pathway to quinazolines is described. This new method uses hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH, starting from simple N-protected anilines. The method affords substituted quinazolines with high