54754-60-8

Basic information

• Product Name: 6,8-Dibromoisatoic anhydride
• Synonyms: 6,8-Dibromoisatoic anhydride;3,5-Dibromoisatoic anhydride;6,8-Dibromo-1H-benzo[d][1,3]oxazine-2,4-dione;2H-3,1-Benzoxazine-2,4(1H)-dione, 6,8-dibromo-;6,8-dibromo-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione
• CAS NO: 54754-60-8
• Molecular Formula: C₈H₃Br₂NO₃
• Molecular Weight: 320.92232
• EINECS: 1533716-785-6
• Mol File: 54754-60-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 263.5 °C
• Appearance: /
• Density: 2.158±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.72±0.20(Predicted)
• CAS DataBase Reference: 6,8-Dibromoisatoic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 6,8-Dibromoisatoic anhydride(54754-60-8)
• EPA Substance Registry System: 6,8-Dibromoisatoic anhydride(54754-60-8)

Safety Data

• Hazardous Substances Data: 54754-60-8(Hazardous Substances Data)

Usage

General Description

6,8-Dibromoisatoic anhydride is a chemical compound with the molecular formula C8H2Br2O3. It is a white to light yellow crystalline solid that is commonly used as a building block in organic synthesis. Its primary function is as a reagent for the preparation of various functionalized aromatic compounds, including pharmaceutical intermediates and organic dyes. It is widely known for its ability to modify natural products and other complex molecules to introduce new functionalities. Due to its versatility and reactivity, 6,8-Dibromoisatoic anhydride is popular in the field of chemical synthesis and is used in research laboratories and industrial settings for the development of new materials and compounds.

Upstream product

• 6374-91-0 5,7-Dibromoisatin 
• 75-44-5 phosgene 
• 609-85-8 2-amino-3,5-dibromobenzoic acid 
• 2475-31-2 5,7-dibromo-2-(5,7-dibromo-1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one 
• 118-92-3 anthranilic acid 

Downstream Products

• 108180-06-9 4-(6,8-Dibromo-4-oxo-4H-quinazolin-3-ylmethyl)-cyclohexanecarboxylic acid 
• 108180-04-7 4-(6,8-Dibromo-4-oxo-4H-benzo[d][1,2,3]triazin-3-ylmethyl)-cyclohexanecarboxylic acid 
• 1072137-92-8 C₂₂H₁₇Br₃ClN₇O₄ 
• 1072138-15-8 C₂₂H₁₈Br₃ClN₆O₄ 
• 1072138-05-6 C₂₁H₁₄Br₃ClN₆O₄ 
• 1072138-64-7 C₁₃H₁₄Br₂N₄O₃ 
• 1072138-88-5 C₁₃H₁₅Br₂N₃O₃ 
• 1072138-79-4 N-(2-amino-3,5-dibromobenzoyl)-N'-methoxycarbonylhydrazine 
• 1072137-83-7 N-(2-amino-3,5-dibromobenzoyl)-N'-methyl-N'-methoxycarbonylhydrazine 
• 1072108-70-3 2-[3,5-dibromo-2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)benzoyl]-2-ethylhydrazinylcarboxylic acid methyl ester 
• 1072137-73-5 N-(2-amino-3,5-dibromobenzoyl)-N-ethyl-N'-methoxycarbonylhydrazine 
• 1072137-81-5 N-(2-amino-3,5-dibromobenzoyl)-N-methyl-N'-methoxycarbonylhydrazine 
• 1423059-30-6 5-bromo-2-(3-chloropyridin-2-yl)-2H-pyrazole-3-carboxylic acid (2,4-dibromo-6-methylcarbamoylmethoxycarbamoylphenyl)amide 
• 1072137-69-9 N-(2-amino-3,5-dibromobenzoyl)-N-ethyl-hydrazine 

Relevant articles and documents

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PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLATE COMPOUNDS AND DERIVATIVES THEREOF

The present invention relates to a process for preparing an N-substituted 1 H-pyrazole- 5- carboxylate compound of the formula (l-A) comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined in the description and the claims, with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a carbonylation by reacting it with a reagent selected from the group consisting carbon dioxide or a carbon dioxide equivalent, to obtain a compound of formula (l-A); and it relates to further conversions to yield a N-substituted 1H-pyrazole-5-carbonyl chloride compound of the formula (I).