548-40-3 Usage
Description
This alkaloid was first obtained by Hesse from Berberis vulgaris and is also a
minor constituent of other Berberis and Mahonia species. When recrystallized
from EtOH it forms clusters of colourless needles, m.p. 208-214°C, the higher
melting point given above being obtained in vacuo. It has [α]D + 131.6°
(CHC13), a much higher value of + 279° (CHCI3) being given by Gericke and
Bruchhausen. The dihydrochloride forms needles, m.p. 270-1°C (vac.); [α] +29
D+ 188.5° (H20) and is only sparingly soluble in dilute HC1; the hydrobromide has
m.p. 273-5°C (dec., vac.) and the nitrate forms colourless needles, m.p. 195-
200°C (dec.). The presence of the phenolic hydroxyl group is indicated by the
formation of an O-benzoy1 derivative, a potassium salt and the O-methyl ether,
giving a hydrochloride, m.p. 261°C. The structure has been deduced from chem_x0002_ical and spectroscopic data. Various colour reactions have been described, e.g.
the alkaloid is not coloured by H2S04, gives a yellow colour with HN03 and
with molybdic acid in H2S04 produces a violet colour, slowly changing to
yellow-green.
Definition
ChEBI: A macrocycle that is oxyacanthan that is substituted by methoxy groups at positions 6, 6', and 7, methyl groups at positions 2 and 2', and a hydroxy group at the 12' position.
Check Digit Verification of cas no
The CAS Registry Mumber 548-40-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 548-40:
(5*5)+(4*4)+(3*8)+(2*4)+(1*0)=73
73 % 10 = 3
So 548-40-3 is a valid CAS Registry Number.
InChI:InChI=1/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)17-23-8-11-30(40)31(18-23)44-26-9-6-22(7-10-26)16-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m1/s1
548-40-3Relevant articles and documents
Cosmetic or pharmaceutical composition, especially dermatological composition, containing oxyacanthine, intended in particular for stimulating hair growth or retarding hair loss
-
, (2008/06/13)
The invention relates to a cosmetic or pharmaceutical composition which comprises oxyacanthine, one of its derivatives, one of their cosmetically or pharmaceutically acceptable acid addition salts or an extract of a plant in which it is present, such as Berberis vulgaris or barberry. One particular association is that of oxyacanthine with a saponin. This composition can be intended in particular for stimulating hair growth, retarding hair loss or combating pruritus.
