54916-28-8

Basic information

• Product Name: 4-ACETYL-4'-METHOXYDIPHENYL ETHER
• Synonyms: 1-[4-(4-METHOXYPHENOXY)PHENYL]ETHAN-1-ONE;1-[4-(4-METHOXY-PHENOXY)-PHENYL]-ETHANONE;4-ACETYL-4'-METHOXYDIPHENYL ETHER;BUTTPARK 52\12-18;4-(4-Methoxyphenoxy)acetophenone;1-[4-(4-Methoxyphenoxy)phenyl]ethan-1-on, 97%;1-[4-(4-Methoxyphenoxy)phenyl]-1-ethanone;1-[4-(4-Methoxyphenoxy)phenyl]ethan-1-one, 4-Acetyl-4'-methoxydiphenyl ether
• CAS NO: 54916-28-8
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.27
• Mol File: 54916-28-8.mol
• Article Data: 32

Chemical Properties

• Melting Point: 56-58°C
• Boiling Point: 198-201°C 2mm
• Flash Point: 198-201°C/2mm
• Appearance: /
• Density: 1.123±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2115929
• CAS DataBase Reference: 4-ACETYL-4'-METHOXYDIPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETYL-4'-METHOXYDIPHENYL ETHER(54916-28-8)
• EPA Substance Registry System: 4-ACETYL-4'-METHOXYDIPHENYL ETHER(54916-28-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• Hazardous Substances Data: 54916-28-8(Hazardous Substances Data)

Usage

General Description

4-ACETYL-4'-METHOXYDIPHENYL ETHER, also known as aMDE, is a chemical compound with the molecular formula C16H16O3. It is a derivative of diphenoxylic acid and belongs to the class of diphenyl ethers. 4-ACETYL-4'-METHOXYDIPHENYL ETHER is commonly used in organic synthesis and pharmaceutical research due to its diverse properties and potential applications. It has also been investigated for its potential therapeutic effects, particularly in the field of neuropharmacology. Additionally, aMDE has been studied for its antioxidant and antiviral activities, making it a valuable subject of research in the field of medicinal chemistry. Overall, 4-ACETYL-4'-METHOXYDIPHENYL ETHER is a versatile chemical with promising potential in various scientific and medical applications.

Upstream product

• 150-76-5 4-methoxy-phenol 
• 100-19-6 (4-nitrophenyl)ethanone 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 248256-02-2 (4-methoxyphenoxymethyl)-(4-fluorophenyl)-ketone 
• 13329-40-3 4-Iodoacetophenone 
• 139-02-6 sodium phenoxide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 1122-95-8 sodium 4-methoxyphenolate 
• 99-90-1 para-bromoacetophenone 
• 77-78-1 dimethyl sulfate 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 1655-69-2 1-methoxy-4-phenoxy-benzene 

Downstream Products

• 1093730-39-2 2-(4-(4-methoxyphenoxy)phenyl)-2-oxoacetic acid 
• 352286-26-1 (E)-(S)-2-ethoxy-3-(4-{3-[4-(4-methoxy-phenoxy)-phenyl]-but-2-enyloxy}-phenyl)-propionic acid ethyl ester 
• 947548-36-9 3-(4-(4-methoxyphenoxy)phenyl)-3-oxopropanal 
• 620633-63-8 1-(3-Fluoro-phenyl)-3-[4-(4-methoxy-phenoxy)-phenyl]-propane-1,3-dione 
• 257609-02-2 1-(4-(4-(benzyloxy)phenoxy)phenyl)ethan-1-one 
• 10181-93-8 4-(4-methoxyphenoxy)phenol 
• 92549-44-5 [4-(4-methoxyphenoxy)phenyl]acetic acid 
• 393796-68-4 5-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-5-[4-(4-methoxy-phenoxy)-phenyl]-pyrimidine-2,4,6-trione 
• 852631-26-6 5-bromo-5-[4-(4-methoxyphenoxy)phenyl]pyrimidine-2,4,6-trione 
• 852631-21-1 5-[4-(4-methoxyphenoxy)phenyl]pyrimidine-2,4,6-trione 
• 852631-17-5 [4-(4-methoxyphenoxy)phenyl]malonic dimethyl ester 
• 852631-12-0 [4-(4-methoxyphenoxy)phenyl]acetic acid methyl ester 
• 86431-73-4 4-methoxyphenyl 4-(chloroisopropyl)phenyl ether 
• 86896-98-2 4-methoxyphenyl 4-(hydroxyisopropyl)phenyl ether 

Relevant articles and documents

Identification of an Oxalamide Ligand for Copper-Catalyzed C?O Couplings from a Pharmaceutical Compound Library

A typical pharmaceutical compound library is stocked with molecular diversity and could provide a platform for the discovery of new ligand structures. Herein, we describe the use of this approach in combination with high throughput screening to identify N,N’-bis(thiophene-2-ylmethyl)oxalamide as a ligand that is generally effective for copper-catalyzed C?O cross-couplings to prepare both biarylethers as well as phenols under mild conditions.

HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE

Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being described in the specifications. The compound represented by formula (I) can be used as the ligand in the copper catalyzed coupling reaction of the aryl halogeno substitute, and is used or catalyzing the coupling reaction for forming the aryl halogeno substitute having C—N, C—O, C—S and other bonds.

Novel EDA transient electron donor-acceptor complex, and preparation method and applications thereof

The invention relates to a novel EDA transient electron donor-acceptor complex, and a preparation method and applications thereof. The structure of the complex is represented in the description, wherein R1 represents an electron-withdrawing group such as cyano, nitro, acetyl, trifluoromethyl, and the like; R2 represents any one substituent group such as hydrogen, an alkyl group (methyl, ethyl, etc.), chlorine, bromine, iodine, methoxyl, nitro, and the like; and the position of the substituent group can be an o-position, m-position, or p-position. According to the synthesis method, under the induction of visible light, phenol derivatives and electron deficient aryl halide carry out reactions under the action of basic cesium carbonate to generate the complex, and no transition metal catalyst, transition metal ligand, or photo oxidation-reduction agent is added. Through the reaction mechanism, a series of diaryl ether derivatives is prepared. The preparation method has the advantages of mild conditions, greenness, high efficiency, low cost, and simple operation.