5496-39-9

Basic information

• Product Name: 1H-Imidazole, 2-(4-nitrophenyl)-4,5-diphenyl-
• CAS NO: 5496-39-9
• Molecular Formula: C21H15N3O2
• Molecular Weight: 341.369
• Mol File: 5496-39-9.mol
• Article Data: 115

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole, 2-(4-nitrophenyl)-4,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 2-(4-nitrophenyl)-4,5-diphenyl-(5496-39-9)
• EPA Substance Registry System: 1H-Imidazole, 2-(4-nitrophenyl)-4,5-diphenyl-(5496-39-9)

Safety Data

• Hazardous Substances Data: 5496-39-9(Hazardous Substances Data)

Usage

1H-Imidazole, 2-(4-nitrophenyl)-4,5-diphenyl-

A chemical compound with a 2-(4-nitrophenyl) imidazole structure, also known as 4,5-diphenyl-2-(4-nitrophenyl)-1H-imidazole.

Organic synthesis

Used in organic synthesis.

Pharmaceutical industry

Used as a building block for the synthesis of various biologically active compounds.

Antifungal properties

Studied for its potential antifungal properties.

Antibacterial properties

Studied for its potential antibacterial properties.

Chemical structure

Contains a nitrophenyl group, which makes it useful for various chemical reactions and as a substrate for the development of new pharmaceutical compounds.

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 134-81-6 benzil 
• 1448032-41-4 1-benzyl-4,5-dibromo-2-(4-nitrophenyl)-1H-imidazole 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 631-61-8 ammonium acetate 
• 619-73-8 4-nitrobenzyl chloride 
• 57-13-6 urea 
• 13295-04-0 1.2-bis(4-nitrophenyl)ethane-1,2-diol 
• 451-40-1 phenyl benzyl ketone 
• 501-65-5 diphenyl acetylene 

Downstream Products

• 102469-74-9 4-(4,5-diphenyl-1H-imidazol-2-yl)aniline 
• 56337-98-5 2,4,5-tris(4-nitrophenyl)-1H-imidazole 
• 918664-38-7 4-(1-ethyl-4,5-diphenylimidazol-2-yl)-phenylamine 
• 918664-36-5 1-methyl-2-(4-aminophenyl)-4,5-diphenyl-1H-imidazole 
• 242149-37-7 1-ethyl-2-(4-nitrophenyl)-4,5-diphenylimidazole 
• 36783-81-0 1-methyl-2-(4-nitrophenyl)-4,5-diphenyl-1H-imidazole 
• 13960-33-3 2-(4-nitrophenyl)-4,6-diphenyl-1,3,5-triazine 

Relevant articles and documents

Synthesis and characterization of a new polymeric catalyst and used for the synthesis of imidazole derivatives

Cross-linked poly (4-vinylpyridine) supported TiCl4 abbreviated as [P4-VP]-Ti(IV) as a new polymeric catalyst was easily prepared and characterized by using the X-ray spectroscopy, EDS, mapping, TGA/DTG and FTIR techniques. This catalyst was used for synthesis of imidazole derivatives via one-pot three-component condensation reaction of benzil, ammonium acetate and aldehydes. This protocol offers advantages such as short reaction time, simple reaction work-up with reusability of catalyst. Graphic abstract: [Figure not available: see fulltext.].

A green and simple method for the synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives using acidic ionic liquid as an effective and recyclable catalyst under ultrasound

Abstract: In the current work, an acidic ionic liquid ([{(IMC)-4-OMBH}BIM][HSO4]3) has been utilized as an effective and recyclable catalyst for the synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives with high yields under optimal reaction conditions and ultrasound irradiation. Important features of the new catalyst are facile synthesis, cheap reagents and successful reuse for many times. What makes the present method an effective contribution in the field of synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives is the fact that it can be described as environmentally friendly, economical, short reaction time, possible recover of the catalyst, simple workup, safer and mild reaction conditions. Graphic abstract: [Figure not available: see fulltext.].

Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction

A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source.