54968-60-4

Basic information

• Product Name: (4-HYDROXY-5,6-DIMETHYL-THIENO[2,3-D]PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID
• Synonyms: TIMTEC-BB SBB007401;(4-HYDROXY-5,6-DIMETHYL-THIENO[2,3-D]PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID
• CAS NO: 54968-60-4
• Molecular Formula: C10H10N2O3S2
• Molecular Weight: 270.33
• Mol File: 54968-60-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-HYDROXY-5,6-DIMETHYL-THIENO[2,3-D]PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-HYDROXY-5,6-DIMETHYL-THIENO[2,3-D]PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID(54968-60-4)
• EPA Substance Registry System: (4-HYDROXY-5,6-DIMETHYL-THIENO[2,3-D]PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID(54968-60-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 54968-60-4(Hazardous Substances Data)

Usage

General Description

(4-HYDROXY-5,6-DIMETHYL-THIENO[2,3-D]PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID, also known as rufinamide, is a medication used to treat seizures associated with Lennox-Gastaut syndrome, a severe form of epilepsy. It works by stabilizing the electrical activity in the brain and reducing the frequency and severity of seizures. Rufinamide is classified as an anti-epileptic drug and is typically prescribed in conjunction with other seizure medications. It is available in tablet and oral suspension forms and is usually taken two to three times daily as directed by a healthcare professional. Rufinamide may cause side effects such as dizziness, drowsiness, nausea, and vomiting, and should not be abruptly discontinued without medical supervision to avoid withdrawal symptoms.

InChI:InChI=1/C10H10N2O3S2/c1-4-5(2)17-9-7(4)8(15)11-10(12-9)16-3-6(13)14/h3H2,1-2H3,(H,13,14)(H,11,12,15)/p-1

Upstream product

• 38201-64-8 5,6-dimethyl-2-thioxo-2,3-dihydro-1H-thieno[2,3-d]pyrimidin-4-one 
• 79-11-8 chloroacetic acid 
• 53162-51-9 2-thio-4-oxo-5,6-dimethyl-3,4-dihydrothieno<2,3-d>pyrimidine potassium salt 
• 53162-53-1 ethyl 4,5-dimethyl-2-(3-benzoylthioureido)-3-thiophenecarboxylate 
• 4815-24-1 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester 
• 60442-34-4 2-(2-chloro-acetylamino)-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester 
• 333-20-0 potassium thioacyanate 
• 64-69-7 Iodoacetic acid 

Relevant articles and documents

New syntheses of 2-alkylthio-4-oxo-3,4-dihydroquinazolines, 2-alkylthioquinazolines, as well as their hetero analogues

N-Chloroacetylanthranilic acid ethyl ester reacts with potassium thiocyanate in the presence of alcohol to give the (4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)acetic acid ester (3a). In the presence of water or amines the acetic acid derivative (3b) or the acetamide derivatives (3c,d) are obtained. 2-Amino-4-oxo-3,4-dihydroquinazolines (4) arise if vigorous reaction conditions are employed. Analogously, N-chloroacetyl derivatives of 5-membered heterocycles with enaminocarbonyl structure (5, 7, 9, 11, 13, 20, 23) react with potassium thiocyanate to yield thieno[2,3-d]-, thieno[3,2-d]-, imidazo[4,5-d]-, pyrrolo[3,2-d]-, and thiazolo[4,5-d]pyrimidines (6, 8, 10, 12, 14, 21, 24). Quinazolines (18, 19) are formed from the reaction of 2-chloroacetylaminoacetophenone (16a) and 2-chloroacetylaminobenzophenone (16b) with potassium thiocyanate and subsequent treatment of the intermediates with amines.