550363-85-4

Basic information

• Product Name: 2-FLUORO-5-FORMYLBENZOIC ACID 95
• Synonyms: 2-FLUORO-5-FORMYLBENZOIC ACID 95;2-Fluoro-5-formylbenzoic acid 95%;3-Carboxy-4-fluorobenzaldehyde;5-(1,3-dioxolan-2-yl)-2-fluorobenzoic acid
• CAS NO: 550363-85-4
• Molecular Formula: C₈H₅FO₃
• Molecular Weight: 168.1225
• Mol File: 550363-85-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 174.5-178.5
• Boiling Point: 330.902 °C at 760 mmHg
• Flash Point: 153.924 °C
• Appearance: /
• Density: 1.427 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.92±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-5-FORMYLBENZOIC ACID 95(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-FORMYLBENZOIC ACID 95(550363-85-4)
• EPA Substance Registry System: 2-FLUORO-5-FORMYLBENZOIC ACID 95(550363-85-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 550363-85-4(Hazardous Substances Data)

Usage

General Description

2-Fluoro-5-formylbenzoic acid 95 is a chemical compound with the molecular formula C8H5FO3. It is a fluoro-substituted formylbenzoic acid, which is commonly used in the synthesis of pharmaceuticals and agrochemicals. 2-Fluoro-5-formylbenzoic acid 95 is known for its functional properties, including its role as a versatile building block for the preparation of various organic molecules. It is also used as a reagent in organic chemistry reactions, particularly in the modification of aromatic compounds. Additionally, 2-Fluoro-5-formylbenzoic acid 95 is integral in the development of new materials and is utilized in research and development for its catalytic and medicinal properties.

InChI:InChI=1/C8H5FO3/c9-7-2-1-5(4-10)3-6(7)8(11)12/h1-4H,(H,11,12)

Upstream product

• 201230-82-2 carbon monoxide 
• 227609-88-3 4-fluoro-3-iodobenzaldehyde 
• 321-12-0 2-fluoro-5-methyl-benzoic acid 
• 218301-22-5 2-fluoro-5-formylbenzonitrile 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 165803-94-1 methyl 2-fluoro-5-formylbenzoate 

Downstream Products

• 165803-94-1 methyl 2-fluoro-5-formylbenzoate 
• 763114-26-7 2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid 
• 1813527-81-9 4-(4-fluoro-3-((piridin-2-ylmethyl)carbamoyl)phenyl)-N-(1H-imidazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 
• 1207454-83-8 ethyl 2-(3-(dimethylcarbamoyl)-4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate 
• 1207454-82-7 (E)-2-fluoro-N,N-dimethyl-5-((1-oxo-1,3-dihydroisobenzofuran-4-ylimino)methyl)benzamide 
• 1207454-80-5 2-Fluoro-N,N-dimethyl-5-(9-(1-methyl-1H-imidazol-2-yl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzamide 
• 1334590-84-9 (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioic acid 
• 1334590-78-1 dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate 
• 1310744-58-1 (R)-1,5-dimethyl 2-(2-fluoro-5-formylbenzamido)pentanedioate 
• 1310744-64-9 (R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid 

Relevant articles and documents

Pharmaceutical composition for use in preventing or treating poly(ADP-ribose)polymerase-1 related diseases containing the same as an active ingredient

The present invention relates to a novel compound, a method for manufacturing the same, and a pharmaceutical composition for preventing or treating poly(ADP-ribose)polymerase-1 (PARP-1) related diseases containing the compound as an active ingredient. The novel PARP-1 inhibitory compound according to the present invention exhibits an excellent PARP-1 inhibitory effect at a concentration of nanomol unit and further exhibits an excellent cytoprotective effect (cell death inhibitory effect) on ophthalmic diseases or disorders, especially on retinal diseases. The composition containing the compound as an active ingredient is useful as a composition for preventing or treating PARP-1 related diseases, for example, ophthalmic diseases or disorders.(AA) Example 37(BB) Example 39COPYRIGHT KIPO 2018

COMPOUNDS ACTIVE TOWARDS BROMODOMAINS

Disclosed are compounds towards bromodomains, pharmaceutical compositions containing the compounds and use of the compounds in therapy.

METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)

Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.