55077-30-0 Usage
Originator
Abovis ,Toyama ,Japan ,1981
Uses
Aclatonium Napadisilate is a useful bioactive therapeutic agent for autoimmune diseases. A cholinergic agonist.
Manufacturing Process
5.2 g of bis(choline)-naphthalene-1,5-disulfonate was suspended in 30 ml of
acetonitrile, and 10 g of lactic acid anhydride diacetate was added thereto.
This mixture was refluxed for 3 hours. The resulting reaction mixture was
allowed to stand at room temperature while cooling to precipitate the desired
product crystals, which were collected by filtration. 5.5 g (76% yield) of the
desired product having a melting point of 189°C to 191°C were obtained.
Therapeutic Function
Cholinergic
Safety Profile
Poison by intravenous route.Moderately toxic by subcutaneous route. An experimentalteratogen. Other experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx andSOx. A cholinergic agent.
Check Digit Verification of cas no
The CAS Registry Mumber 55077-30-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,0,7 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 55077-30:
(7*5)+(6*5)+(5*0)+(4*7)+(3*7)+(2*3)+(1*0)=120
120 % 10 = 0
So 55077-30-0 is a valid CAS Registry Number.
InChI:InChI=1/2C10H20NO4.C10H8O6S2/c2*1-8(15-9(2)12)10(13)14-7-6-11(3,4)5;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16/h2*8H,6-7H2,1-5H3;1-6H,(H,11,12,13)(H,14,15,16)/q2*+1;/p-2
55077-30-0Relevant articles and documents
Industrial preparation method of aclatonium napadisilate
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Paragraph 0051-0053, (2019/11/13)
The invention discloses an industrial preparation method of aclatonium napadisilate. The industrial preparation method comprises the following steps that lactic acid reacts with acetic anhydride, chloroformate and N,N-dimethylethanolamine in sequence to obtain acetyllactylcholine, acetyllactylcholine is added with acid to be prepared into a salt and then separated, and a product reacts with 1,5-naphthalenedisulfonic acid dimethyl ester to obtain aclatonium napadisilate. The industrial preparation method has the advantages that aclatonium napadisilate is prepared by a ''mixed acid anhydride strategy'', and the use of a volatile highly corrosive reagent can be avoided; water can be used as a solvent for preparation of an intermediate, and the amount of an organic solvent can be avoided or reduced; a ''one-pot method'' can be adopted to prepare the intermediate to reduce unit operation; the solvent can be directly added for crystallization in the post-processing process of the preparationof a finished product to improve the purity of the product; and the reaction scale can be enlarged to more than ten kilograms.
