5511-18-2

Basic information

• Product Name: 1-ADAMANTANECARBOXAMIDE
• Synonyms: SALOR-INT L496057-1EA;OTAVA-BB BB5030040657;1-Adamantyl-carboxamide;tricyclo(3.3.1.1(sup3,7))decane-1-carboxamide;Tricyclo(3.3.1.13,7)decane-1-carboxamide;LABOTEST-BB LT00007835;1-ADAMANTANECARBOXAMIDE;ADAMANTANE-1-CARBOXAMIDE
• CAS NO: 5511-18-2
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.26
• EINECS: 234-074-2
• Product Categories: Adamantane derivatives;Adamantanes;Intermediates & Fine Chemicals;Pharmaceuticals;Amides;Carbonyl Compounds;Organic Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 5511-18-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 188-190 °C(lit.)
• Boiling Point: 311.8°C (rough estimate)
• Flash Point: 161.4 °C
• Appearance: white solid
• Density: 1.0020 (rough estimate)
• Vapor Pressure: 7.09E-05mmHg at 25°C
• Refractive Index: 1.5065 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Dichloromethane, Methanol
• PKA: 16.85±0.20(Predicted)
• BRN: 2047887
• CAS DataBase Reference: 1-ADAMANTANECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ADAMANTANECARBOXAMIDE(5511-18-2)
• EPA Substance Registry System: 1-ADAMANTANECARBOXAMIDE(5511-18-2)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: AU4452000
• HazardClass: IRRITANT
• Hazardous Substances Data: 5511-18-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Reproduction of Sindbis virus strains sensitive and resistant to 1-adamantanecarboxamide

InChI:InChI=1/C11H17NO/c12-10(13)11-4-7-1-8(5-11)3-9(2-7)6-11/h7-9H,1-6H2,(H2,12,13)

Upstream product

• 770-71-8 1-adamantanemethanol 
• 828-51-3 1-Adamantanecarboxylic acid 
• 75-05-8 acetonitrile 

Downstream Products

• 151476-40-3 N-tert-butyl adamantan-1-yl-carbamate 
• 23074-42-2 1-adamantanecarbonitrile 
• 768-94-5 1-Adamantanamine 
• 119045-27-1 1-adamantane ammonium tosylate 
• 413610-66-9 N-(2-acetylphenyl)adamantane-1-carboxamide 
• 1214747-90-6 1,3-Ad'(CONH₂)(CONC₅H₁₀) 
• 53263-89-1 1-bromo-3-carboxamidoadamantane 
• 770-71-8 1-adamantanemethanol 
• 645403-23-2 N-adamantan-1-ylmethyl-(2-chloro-5-methoxy)-benzamide 
• 828-51-3 1-Adamantanecarboxylic acid 
• 1501-98-0 1-adamantylmethylamine hydrochloride 
• 1050521-32-8 (S)-4-((tert-butyldiphenylsilyloxy)methyl)-1-(1-adamantylmethyl)imidazolidin-2-one 
• 1050520-88-1 1-(4-(benzyloxy)phenyl)-2-((1-adamantylmethyl)amino)ethanol 
• 1050520-92-7 (S)-3-((1-adamantyl)methyl)-5-cyclohexyloxazolidin-2-one 

Relevant articles and documents

Metal-free one-pot oxidative conversion of benzylic alcohols and benzylic halides into aromatic amides with molecular iodine in aq ammonia, and hydrogen peroxide

Various primary alcohols, particularly benzylic alcohols, could be converted into the corresponding aromatic amides in good yields in a one-pot manner by treatment with molecular iodine in aq. NH3, followed by reaction with ～30% aq H2O2. Similarly, various benzylic halides could be also converted into the corresponding aromatic amides in good yields in a one-pot manner by treatment with molecular iodine in aq NH3, followed by reaction with ～30% aq H2O 2. The present reactions involve the metal-free one-pot oxidative conversion of benzylic alcohols and benzylic halides into the corresponding aromatic amides, respectively.