55154-42-2Relevant articles and documents
Preparation method of azelastine key intermediate N-methylhexahydroazepine-4-ketone hydrochloride
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Paragraph 0050-0055; 0068-0071; 0094-0098, (2020/12/30)
The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of an azelastine key intermediate N-methylhexahydroepine-4-ketone hydrochloride. Aiming at the problems that in the prior art, a synthetic route of N-methylhexahydroepine-4-ketone hydrochloride uses more organic raw materials, so that the cost is increased, the environmental protection is not facilitated, and the impurity content in a product is increased, the technical scheme of the invention is as follows: N-methyl-2-pyrrolidone is used as an initial raw material and is subjected to alkaline hydrolysis, and substitution addition and esterification are sequentially carried out, and then cyclization is carried out to synthesize the azelastine key intermediate. The method issuitable for industrial production of the azelastine key intermediate N-methylhexahydroepine-4-ketone hydrochloride.
Selective conversion of glycerol to lactic acid with iron pincer precatalysts
Sharninghausen, Liam S.,Mercado, Brandon Q.,Crabtree, Robert H.,Hazari, Nilay
supporting information, p. 16201 - 16204 (2015/11/16)
A family of iron complexes of PNP pincer ligands are active catalysts for the conversion of glycerol to lactic acid with high activity and selectivity. These complexes also catalyse transfer hydrogenation reactions using glycerol as the hydrogen source.