552331-06-3Relevant articles and documents
Synthesis of medical intermediate disubstituted N-containing heterocycle amine compound
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Paragraph 0017; 0019; 0022; 0024; 0027; 0029; 0032; 0034, (2019/01/06)
The invention relates to synthesis of a medical intermediate disubstituted N-containing heterocycle amine compound. The synthesis comprises the following steps: reacting 5-bromo-2-carboxy-phenylaceticacid, urea and o-dichlorobenzene as raw materials to obtain 6-bromoisoquinoline-1, 3 (2H,4H)-dione; allowing the 6-bromoisoquinoline-1, 3 (2H,4H)-dione to react with phenyl dichloro sphosphineoxide,adding tetrahydrofuran to precipitate out, adjusting the pH value, and then passing through a column to obtain 1, 3-dichloro-6-bromoisoquinoline; then adding glacial acetic acid, red phosphorus and hydroiodic acid, and after the reaction, determining whether the reaction is complete or not by TLC, subjecting the filtrate and the filter cake to repeated fine treatment to obtain 3-chloro-6-bromoisoquinoline; adding copper sulfate pentahydrate, 6-bromo-3-chloroisoquinoline and a large amount of 15% ammonia water to react in a high-pressure kettle, extracting and passing column for many times according to different requirements to obtain the final product 3-chloro-6-aminoisoquinoline.
Kinase inhibitors
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Page/Page column 34-35, (2010/01/31)
Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.