552333-48-9

Basic information

• Product Name: (2S)-{1-[(5-bromo-pyridin-3-ylamino)-methyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
• Synonyms: (2S)-{1-[(5-bromo-pyridin-3-ylamino)-methyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
• CAS NO: 552333-48-9
• Molecular Weight: 406.322
• Mol File: 552333-48-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S)-{1-[(5-bromo-pyridin-3-ylamino)-methyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-{1-[(5-bromo-pyridin-3-ylamino)-methyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester(552333-48-9)
• EPA Substance Registry System: (2S)-{1-[(5-bromo-pyridin-3-ylamino)-methyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester(552333-48-9)

Safety Data

• Hazardous Substances Data: 552333-48-9(Hazardous Substances Data)

Upstream product

• 13535-01-8 3-amino-5-bromopyridine 
• 103127-53-3 N-tert-butyloxycarbonyl-2-amino-3-phenylpropionaldehyde 
• 72155-45-4 Boc-L-phenylalaninal 

Relevant articles and documents

Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase

Based on lead compounds 2 and 3 a series of 3,5-disubstituted pyridines have been designed and evaluated for inhibition of AKT/PKB. Modifications at the 3 position of the pyridine ring led to a number of potent compounds with improved physical properties, resulting in the identification of 11g as a promising, orally active Akt inhibitor. The synthesis, structure-activity relationship studies, and pharmacokinetic data are presented in this paper.