55308-52-6Relevant articles and documents
2-Substituted phenyl-s-triazolo[5,1-a] isoquinoline compounds
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, (2008/06/13)
A new process for preparing s-triazolo[5,1-a]-isoquinoline derivatives of the formula STR1 wherein A represents the group --CH2 --CH2 -- or --CH=CH--; R is selected from hydrogen, amino, lower alkylamino, di-lower alkylamino, acylamino, diacylamino, ureido, thioureido, carbethoxythioureido, benzoylthioureido, sulfhydryl, lower alkyl, trifluoromethyl, phenyl, substituted phenyl, pyridyl, methylpyridyl and dimethylpyridyl; and R1 and R2 each independently represents hydrogen or lower alkoxy, by condensation of a 2-amino-3,4-dihydro-1(2H)-isoquinolinone with an imidolyl, cyanamide, cyanic or thiocyanic derivative. New compounds of the formula I wherein A represents the group --CH2 --CH2 -- or --CH=CH--, R has the same meaning as above with the exclusion of hydrogen, methyl, phenyl, and trifluoromethyl, R1 and R2 have the same meaning as above, with the proviso that when A represents the group --CH=CH--, R cannot be tolyl or pyridyl. The new compounds and some of the intermediates of the process are active as antiinflammatories, CNS depressants and anti-fertility agents.
Triazolo isoindole derivatives
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, (2008/06/13)
New s-triazolo[5,1-a]isoindole derivatives of following formula I STR1 wherein R is selected from hydrogen, amino, lower alkyl amino, di-lower alkyl amino, acylamino, diacylamino, benzoylamino, ureido, thioureido, carbethoxythioureido, benzoylthioureido,
