55364-67-5

Basic information

• Product Name: methyl 6-methoxy-2-benzofurancarboxylate
• Synonyms: methyl 6-methoxy-2-benzofurancarboxylate;6-Methoxy-2-benzofurancarboxylic acid methyl ester;6-Methoxybenzofuran-2-carboxylic acid methyl ester;2-Benzofurancarboxylic acid, 6-Methoxy-, Methyl ester;Methyl 6-Methoxybenzofuran-2-carboxylate
• CAS NO: 55364-67-5
• Molecular Formula: C₁₁H₁₀O₄
• Molecular Weight: 206.1947
• EINECS: 259-614-4
• Mol File: 55364-67-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 94.2-95.2 °C(Solv: water (7732-18-5); methanol (67-56-1))
• Boiling Point: 301.4°C at 760 mmHg
• Flash Point: 136.1°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 0.00106mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: methyl 6-methoxy-2-benzofurancarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 6-methoxy-2-benzofurancarboxylate(55364-67-5)
• EPA Substance Registry System: methyl 6-methoxy-2-benzofurancarboxylate(55364-67-5)

Safety Data

• Hazardous Substances Data: 55364-67-5(Hazardous Substances Data)

Usage

General Description

Methyl 6-methoxy-2-benzofurancarboxylate is a chemical compound with the molecular formula C11H10O4. It is a derivative of benzofuran and is commonly used in the synthesis of pharmaceuticals and agrochemicals. methyl 6-methoxy-2-benzofurancarboxylate is known for its mild, sweet, and floral aroma, which makes it suitable for use as a fragrance in cosmetics and personal care products. Additionally, it has been studied for its potential anticancer and antidiabetic properties. Methyl 6-methoxy-2-benzofurancarboxylate is also used in the flavor and fragrance industry to impart a fruity and balsamic note to various products.

InChI:InChI=1/C11H10O4/c1-13-8-4-3-7-5-10(11(12)14-2)15-9(7)6-8/h3-6H,1-2H3

Upstream product

• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 96-32-2 bromoacetic acid methyl ester 
• 50551-63-8 6-methoxybenzofuran 
• 50551-61-6 6-methoxybenzofuran-2-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 150-19-6 O-methylresorcine 
• 81720-20-9 methyl (3-methoxyphenoxy)acetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 653578-60-0 methyl 2-ethyl-6-hydroxy-2,3-dihydro-1-benzofuran-2-carboxylate 
• 50551-61-6 6-methoxybenzofuran-2-carboxylic acid 
• 13849-05-3 methyl 6-(benzyloxy)benzofuran-2-carboxylate 

Relevant articles and documents

anti-oxidant composition comprising resveratrol analogues

The present invention provides an antioxidant composition containing a compound represented by chemical formula 1 as an antioxidant active component. In the chemical formula 1, X is O, S, or Se, and each R is independently selected from among hydrogen, an alkyl group having 1 to 12 carbon atoms, and an arylalkyl group having 7 to 15 carbon atoms. The present invention exhibits an excellent antioxidative effect, thereby being useful as the antioxidant composition.COPYRIGHT KIPO 2019

Efficient synthetic approach to substituted benzo[b]furans and benzo[b]thiophenes by iodine-promoted cyclization of enaminones

An efficient synthetic approach to the substituted benzo[b]furan and benzo[b]thiophene scaffolds by iodine-mediated cyclization of the corresponding enaminones is described. This protocol was applied to a large series of these latter precursors to afford the respective benzoheterocycles substituted at the C-2 position by a carbonyl group functionality. A study of the factors that control this process reveals that the reactivity depends on the presence of electron-donor groups in the aryl ring of the aryloxycarbonylic and arylthiocarbonylic moieties.

An efficient synthesis of benzofurans and their application in the preparation of natural products of the genus Calea

The intramolecular cyclization of the β-substituted olefins methyl 2-aryloxy-3-dimethylaminopropenoates 3a-3f catalyzed by Lewis acids leads to a short and novel synthesis of benzofurans 2a-2f. When the olefins 4-dimethylamino-3-aryloxy-3-buten-2-ones 4a-4f were used, the cyclization process was faster and provided the corresponding substituted 2-acetylbenzofurans 1a-1f. Among the latter, naturally occurring compounds calebertin (1a), caleprunin A (1b), and caleprunin B (1c) were prepared in good overall yields. These benzofurans were also obtained by direct treatment under MW irradiation of the precursors 1-aryloxypropan-2-ones 7a-7c with DMFDMA, followed by addition of the catalyst, resulting in a route that was one step shorter.