553652-34-9 Usage
Description
N-(2-bromophenyl)-N-methyl-methanesulfonamide, commonly known as NBS or N-bromosuccinimide, is an organic compound that serves as a radical initiator and a reagent for selective bromination in organic synthesis. It is a white to off-white crystalline powder with limited solubility in water. NBS is highly valued for its selective bromination capabilities in the presence of other functional groups, making it an essential tool in organic chemistry. It is also a mild and convenient source of bromine for creating carbon-bromine bonds in various synthetic applications.
Uses
Used in Organic Synthesis:
NBS is used as a reagent for selective bromination at allylic and benzylic positions, allowing chemists to introduce bromine atoms into specific locations within organic molecules. This selective bromination is crucial for the synthesis of complex organic compounds and the development of new pharmaceuticals and materials.
Used in the Formation of Carbon-Bromine Bonds:
NBS serves as a mild and convenient source of bromine for the formation of carbon-bromine bonds in various synthetic applications. This is particularly useful in the synthesis of organic compounds that require bromine atoms for their biological activity or chemical properties.
Used as a Bleaching Agent:
In the food industry, NBS is utilized as a bleaching agent for edible oils and fats. Its ability to bleach these products enhances their appearance and extends their shelf life, making it a valuable component in food processing.
Safety Precautions:
It is important to handle NBS with care, as it can be a mild irritant to the skin, eyes, and respiratory system. Proper safety measures, such as wearing protective clothing and using appropriate ventilation, should be taken to minimize potential health risks during its use in laboratory and industrial settings.
Check Digit Verification of cas no
The CAS Registry Mumber 553652-34-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,5,3,6,5 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 553652-34:
(8*5)+(7*5)+(6*3)+(5*6)+(4*5)+(3*2)+(2*3)+(1*4)=159
159 % 10 = 9
So 553652-34-9 is a valid CAS Registry Number.
553652-34-9Relevant articles and documents
CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF
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Paragraph 0104; 0110, (2018/03/25)
Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b' to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.
Synthesis of spiropyrrolidinyl-benzoisothiazoline derivatives by 1,3-dipolar cycloaddition of benzoisothiazole-2,2-dioxide-3-ylidenes and azomethine ylide
Cao, Guorui,Long, Feifei,Zhao, Yingchun,Wang, Yu,Huang, Longjiang,Teng, Dawei
, p. 9359 - 9365 (2015/03/05)
The new spirocyclic compounds, spiropyrrolidinyl-benzoisothiazoline derivatives were synthesized by the 1,3-dipolar cycloaddition of benzoisothiazole-2,2-dioxide-3-ylidenes and azomethine ylide. The stereochemistry of 1,3-dipolar cycloaddition as well as the stereochemistry of Knoevenagel condensation of benzoisothiazole-2,2-dioxide with aldehydes were studied.
