55458-83-8

Basic information

• Product Name: Propanoic acid, 2-[4-(aminomethyl)phenoxy]-2-methyl-, ethyl ester
• CAS NO: 55458-83-8
• Molecular Formula: C13H19NO3
• Molecular Weight: 237.299
• Mol File: 55458-83-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-[4-(aminomethyl)phenoxy]-2-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-[4-(aminomethyl)phenoxy]-2-methyl-, ethyl ester(55458-83-8)
• EPA Substance Registry System: Propanoic acid, 2-[4-(aminomethyl)phenoxy]-2-methyl-, ethyl ester(55458-83-8)

Safety Data

• Hazardous Substances Data: 55458-83-8(Hazardous Substances Data)

Upstream product

• 872415-35-5 2-[4-(tert-butoxycarbonylamino-methyl)-phenoxy]-2-methyl-propionic acid ethyl ester 
• 767-00-0 4-cyanophenol 
• 600-00-0 ethyl 2-bromoisobutyrate 
• 18672-07-6 2-(4-cyanophenoxy)-2-methylpropionic acid ethyl ester 

Downstream Products

• 850534-94-0 ethyl 2-methyl-2-[(4-{[({4-methyl-5-[4-(1-methylethyl)phenyl]-1,3-thiazol-2-yl}carbonyl)amino]methyl}phenyl)oxyl]propanoate 
• 343321-97-1 N-methyl-2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethylphenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester 
• 343322-10-1 2-methyl-2-[4-{[(4-methyl-2-[4-aminophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester 

Relevant articles and documents

Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor α agonists

Starting from the structure of 5, a two-step strategy was applied to identify a new generation of trifluoromethane sulfonamides as potent PPARα agonists. Synthesis, in vitro and in vivo evaluation of the most potent compound are reported.

Substituted compounds derived from N-(benzyl)phenylacetamide, preparation and uses

This invention relates to poly-substituted derivatives of the N-(benzyl)phenylacetamide type, pharmaceutical compositions comprising same, therapeutic uses thereof, more particularly in the fields of human and animal health. This invention also relates to a process for the preparation of such derivatives.

SUBSTITUTED PYRAZOLES AS PPAR AGONISTS

A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof (I) wherein: p is O or 1; q is O or 1; R1 and R2 are independently H or C1-3 alkyl; R3 and R4 are independently H, C1-6 alkyl, -OC1-6 alkyl, halogen, OH, C2-6 alkenyl or CF3; R5 is H, C1-6 alkyl (optionally substituted by one or more halogens, -COphenyl, OC1-6 alkyl, phenyl morpholino or C2-6 alkenyl. R6 is C1-6 alkyl, halogen, -OCH2 phenyl, phenyl (optionally substituted by C1-3 alkiyl), morpholino, pyrrolidino, piperidino, thiophenyl, furanyl pyridinyl or -OC2-6 alkenyl. These compounds activate the alpha and gamma subtypes fo the hppar receptor and are useful e.g. in the treatment of diabetes, dyslipidemia or syndrome X.