5549-48-4

Basic information

• Product Name: H-Trp-Met-Asp-Phe-NH₂*TFA
• CAS NO: 5549-48-4
• Molecular Weight: 710.731
• Mol File: 5549-48-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: H-Trp-Met-Asp-Phe-NH₂*TFA(CAS DataBase Reference)
• NIST Chemistry Reference: H-Trp-Met-Asp-Phe-NH₂*TFA(5549-48-4)
• EPA Substance Registry System: H-Trp-Met-Asp-Phe-NH₂*TFA(5549-48-4)

Safety Data

• Hazardous Substances Data: 5549-48-4(Hazardous Substances Data)

Upstream product

• 5235-21-2 N-tert-butoxycarbonyl-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 23446-11-9 tert-butyloxycarbonylmethionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide 
• 25691-61-6 Boc-Nle-Gly-Trp-Met-Asp-Phe-NH₂ 
• 130832-13-2 Boc-Met-Pro-Trp-Met-Asp-Phe-NH₂ 

Relevant articles and documents

PAPAIN-CATALYZED FRAGMENT SYNTHESIS OF PROTECTED CHOLECYSTOKININ DERIVATIVES

Sodium salts of methyl esters of N-tert-butyloxycarbonyl-β-tert-butylaspartyl-O4-sulfotyrosine (II) or N-tert-butyloxycarbonyl-O4-sulfotyrosine (III) were condensed with amino components derived from peptide amides IVb-IVe and IVg (simulating the carboxy-terminal part of cholecystokinin) under catalysis with papain.Rates and yields of conversion of these peptides to the corresponding derivatives Ib-If were compared with the results reported previously for analogous papain-catalyzed fragment synthesis of the protected carboxy-terminal octapeptide of cholecystokinin Ia.In the condensation reactions with the individual amino components quantitative changes were observed in the ability of papain to catalyze the peptide bond synthesis which appeared as differences in the maximum yield (and the time required for achieving it) of the condensation reaction, monitored by HLPC.The observed differences are related not only with the distance of the amino acid substitution from the P'1 subsite in the given amino component but also with the side-chain structure of the substituting amino acid.