55505-26-5

Basic information

• Product Name: 8-Methyl-1 -nonanol
• CAS NO: 55505-26-5
• Molecular Formula: C₁₀H₂₂O
• Molecular Weight: 158.28
• Mol File: 55505-26-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 213.378 °C at 760 mmHg
• Flash Point: 87.141 °C
• Appearance: /
• Density: 0.827 g/cm³
• CAS DataBase Reference: 8-Methyl-1 -nonanol(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methyl-1 -nonanol(55505-26-5)
• EPA Substance Registry System: 8-Methyl-1 -nonanol(55505-26-5)

Safety Data

• Hazardous Substances Data: 55505-26-5(Hazardous Substances Data)

Upstream product

• 54247-27-7 1-bromo-6-benzyloxyhexane 
• 64-17-5 ethanol 

Downstream Products

• 67953-27-9 oleic acid-(8-methyl-nonyl ester) 
• 55504-89-7 (8-Methyl-nonyloxysulfonyl)-phenyl-acetic acid 
• 1346599-15-2 isodecyl diphenyl phosphate 
• 838-85-7 diphenyl hydrogen phosphate 
• 108-95-2 phenol 
• 89-16-7 diisodecyl phthalate 
• 951221-76-4 8-methylnonyl homovanillate 
• 62950-20-3 dibutyl cyclohexane-1,2-dicarboxylate 
• 890090-93-4 isodecyl benzoate 
• 951221-77-5 8-methylnonyl 3-(4-hydroxy-3-methoxyphenyl)propionate 
• 136539-94-1 (8-Methyl-nonyl)-triphenyl-phosphonium; bromide 
• 5129-54-4 8-methylnonanoic acid methyl ester 

Relevant articles and documents

Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3and et Using Matrix Metalloproteinases As Structural Probes

Matrix metalloproteinases (MMPs) are involved in a spectrum of physiological processes, rendering them attractive targets for small-molecule drug discovery. Strategies to achieve selective inhibition continue to be intensively pursued, facilitated by advances in structural biology. Herein, we harness MMPs 2, 8, 9, and 13 to validate the vicinal difluoro motif as a hybrid bioisostere of CF3 and Et (BITE) in a series of modified barbiturate inhibitors. Crystallographic analyses of representative structures reveal conformations of the vicinal difluoro motif that manifest stabilizing hyperconjugative interactions consistent with the stereoelectronic gauche effect. Detailed docking studies of a potent difluorinated probe with MMP-9 are also disclosed and indicate that the structural basis of inhibition is a consequence of the anisotropic nature of the motif. Significant selectivity of MMP 13 versus MMP-2 can be achieved by subtle chain contraction in a BITE-modified inhibitor.