55601-20-2 Usage
Description
Benzeneethanamine, b-fluoro-, also known as 2-Fluoro-2-phenylethan-1-amine, is an organic compound with the molecular formula C8H10FN. It is a derivative of benzeneethanamine, featuring a fluorine atom at the beta position (β) relative to the amine group. Benzeneethanamine, b-fluorois characterized by its potential reactivity and applications in the synthesis of various fluoro amine compounds.
Uses
Used in Pharmaceutical Industry:
Benzeneethanamine, b-fluorois used as a reactant for the preparation of fluoro amines, which are important intermediates in the synthesis of pharmaceutical compounds. The reaction of aziridines with hydrogen fluoride in pyridine solution allows for the production of these valuable building blocks, which can be further utilized in the development of novel drugs with improved properties, such as enhanced bioavailability, selectivity, and reduced side effects.
Used in Chemical Synthesis:
In the field of chemical synthesis, Benzeneethanamine, b-fluoroserves as a versatile building block for the creation of a wide range of fluorinated organic compounds. These compounds find applications in various industries, including agrochemicals, materials science, and specialty chemicals. The presence of the fluorine atom in the molecule can significantly influence the reactivity, stability, and physical properties of the resulting products, making them suitable for specific applications.
Used in Research and Development:
Benzeneethanamine, b-fluorois also utilized in research and development settings, where it can be employed as a starting material or a synthetic intermediate for the exploration of new chemical reactions and the development of innovative molecular structures. Benzeneethanamine, b-fluoro-'s unique properties make it an attractive candidate for studying the effects of fluorination on molecular behavior and reactivity, contributing to the advancement of chemical knowledge and the discovery of new applications.
Check Digit Verification of cas no
The CAS Registry Mumber 55601-20-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,6,0 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 55601-20:
(7*5)+(6*5)+(5*6)+(4*0)+(3*1)+(2*2)+(1*0)=102
102 % 10 = 2
So 55601-20-2 is a valid CAS Registry Number.
55601-20-2Relevant articles and documents
Iron(II)-Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion
Lu, Deng-Fu,Zhu, Cheng-Liang,Sears, Jeffrey D.,Xu, Hao
supporting information, p. 11360 - 11367 (2016/10/12)
We herein report a new catalytic method for intermolecular olefin aminofluorination using earth-abundant iron catalysts and nucleophilic fluoride ion. This method tolerates a broad range of unfunctionalized olefins, especially nonstyrenyl olefins that are incompatible with existing olefin aminofluorination methods. This new iron-catalyzed process directly converts readily available olefins to internal vicinal fluoro carbamates with high regioselectivity (N vs F), many of which are difficult to prepare using known methods. Preliminary mechanistic studies demonstrate that it is possible to exert asymmetric induction using chiral iron catalysts and that both an iron-nitrenoid and carbocation species may be reactive intermediates.
SELECTIVE REDUCTION OF β-FLUOROAZIDES TO β-FLUOROAMINES
Hamman, S.,Beguin, C.G.
, p. 191 - 196 (2007/10/02)
Three methods were tested to reduce chemoselectively β-fluoroazides into β-fluoroamines : catalytic hydrogenation, catalytic transfer hydrogenation, and reduction with triphenyl phosphine.The last was the best.
